Document Detail

A systematic review of the effect of oral antioxidants on male infertility.
MedLine Citation:
PMID:  20378409     Owner:  NLM     Status:  MEDLINE    
The use of antioxidants in treatment of infertile men has been suggested, although the evidence base for this practice is unclear. A systematic review of randomized studies was conducted to evaluate the effects of oral antioxidants (vitamins C and E, zinc, selenium, folate, carnitine and carotenoids) on sperm quality and pregnancy rate in infertile men. MEDLINE, EMBASE, Cochrane Library and CINAHL were searched for relevant trials published from respective database inception dates to May 2009. Study selection, quality appraisal and data extraction were performed independently and in duplicate. Seventeen randomized trials, including a total of 1665 men, were identified, which differed in the populations studied and type, dosage and duration of antioxidants used. Only two-thirds of the studies (11/17) reported using allocation concealment and three studies (18%) used intention-to-treat analysis. Despite the methodological and clinical heterogeneity, 14 of the 17 (82%) trials showed an improvement in either sperm quality or pregnancy rate after antioxidant therapy. Ten trials examined pregnancy rate and six showed a significant improvement after antioxidant therapy. The use of oral antioxidants in infertile men could improve sperm quality and pregnancy rates. Adequately powered robust trials of individual and combinations of antioxidants are needed to guide clinical practice.
C Ross; A Morriss; M Khairy; Y Khalaf; P Braude; A Coomarasamy; T El-Toukhy
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-10
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  20     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  711-23     Citation Subset:  IM    
Copyright Information:
2010. Published by Elsevier Ltd.
Assisted Conception Unit, Guy's and St. Thomas' Hospital NHS Foundation Trust, 11th Floor Tower Wing, Guy's Hospital, St. Thomas Street, London SE19RT, UK.
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MeSH Terms
Administration, Oral
Antioxidants / administration & dosage,  therapeutic use*
Infertility, Male / drug therapy*
Ovulation Induction
Pregnancy Rate
Randomized Controlled Trials as Topic
Reg. No./Substance:

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