| A systematic review of the effect of oral antioxidants on male infertility. | |
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MedLine Citation:
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PMID: 20378409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of antioxidants in treatment of infertile men has been suggested, although the evidence base for this practice is unclear. A systematic review of randomized studies was conducted to evaluate the effects of oral antioxidants (vitamins C and E, zinc, selenium, folate, carnitine and carotenoids) on sperm quality and pregnancy rate in infertile men. MEDLINE, EMBASE, Cochrane Library and CINAHL were searched for relevant trials published from respective database inception dates to May 2009. Study selection, quality appraisal and data extraction were performed independently and in duplicate. Seventeen randomized trials, including a total of 1665 men, were identified, which differed in the populations studied and type, dosage and duration of antioxidants used. Only two-thirds of the studies (11/17) reported using allocation concealment and three studies (18%) used intention-to-treat analysis. Despite the methodological and clinical heterogeneity, 14 of the 17 (82%) trials showed an improvement in either sperm quality or pregnancy rate after antioxidant therapy. Ten trials examined pregnancy rate and six showed a significant improvement after antioxidant therapy. The use of oral antioxidants in infertile men could improve sperm quality and pregnancy rates. Adequately powered robust trials of individual and combinations of antioxidants are needed to guide clinical practice. |
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Authors:
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C Ross; A Morriss; M Khairy; Y Khalaf; P Braude; A Coomarasamy; T El-Toukhy |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-10 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 20 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: Netherlands |
Other Details:
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Languages: eng Pagination: 711-23 Citation Subset: IM |
Copyright Information:
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2010. Published by Elsevier Ltd. |
Affiliation:
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Assisted Conception Unit, Guy's and St. Thomas' Hospital NHS Foundation Trust, 11th Floor Tower Wing, Guy's Hospital, St. Thomas Street, London SE19RT, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Antioxidants / administration & dosage, therapeutic use* Female Humans Infertility, Male / drug therapy* Male Ovulation Induction Pregnancy Pregnancy Rate Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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