| A systematic review of cardiovascular effects after atypical antipsychotic medication overdose. | |
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MedLine Citation:
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PMID: 19497468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As the use of atypical antipsychotic medications (AAPMs) increases, the number of overdoses continues to grow. Cardiovascular toxicity was common with older psychiatric medications but seems uncommon with AAPM. We conducted a systematic literature review to describe the cardiovascular effects reported after overdose of 5 common AAPM: aripiprazole, olanzapine, quetiapine, risperidone, and ziprasidone. We included case reports and case series describing overdose of these 5 medications identified in a search of MEDLINE, EMBASE, and abstracts from major toxicology meetings. We found 13 pediatric cases (age, <7 years), 22 adolescent cases (age, 7-16 years), and 185 adult cases. No pediatric case described a ventricular dysrhythmia or a cardiovascular death. In the adolescent and adult cases, we found numerous reports of prolonged corrected QT interval and hypotension, but there were only 3 cases of ventricular dysrhythmia and 3 deaths that may have been due to direct cardiovascular toxicity. The results from case series reports were similar to the single case report data. Our review suggests that overdose of AAPM is unlikely to cause significant cardiovascular toxicity. |
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Authors:
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Hock Heng Tan; Jason Hoppe; Kennon Heard |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: The American journal of emergency medicine Volume: 27 ISSN: 1532-8171 ISO Abbreviation: Am J Emerg Med Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-05 Completed Date: 2009-07-07 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 607-16 Citation Subset: IM |
Affiliation:
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Accident and Emergency Department, Changi General Hospital, SingHealth, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antipsychotic Agents
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poisoning* Benzodiazepines / poisoning Cardiovascular System / drug effects* Dibenzothiazepines / poisoning Humans Overdose Piperazines / poisoning Quinolones / poisoning Risperidone / poisoning Thiazoles / poisoning |
| Grant Support | |
ID/Acronym/Agency:
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DA 620573/DA/NIDA NIH HHS; K08 DA020573-02/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/Piperazines; 0/Quinolones; 0/Thiazoles; 0/quetiapine; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 129722-12-9/aripiprazole; 132539-06-1/olanzapine; 146939-27-7/ziprasidone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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