Document Detail

A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia.
MedLine Citation:
PMID:  21999904     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Identifying the relative strength of evidence associated with non-genetic risk factors and putative antecedents of schizophrenia will guide research and may inform the design of early detection and intervention strategies.
AIMS: To present and quality assess current evidence for non-genetic risk factors and putative antecedents derived from well-conducted systematic reviews that report pooled data.
METHOD: Medline, Embase, CINAHL, Current Contents, and PsycINFO databases were searched systematically, and supplemented by hand searching. Review reporting quality was assessed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist, review methodology was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) checklist, and evidence quality was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
RESULTS: Twenty-four reviews met inclusion criteria. The risk factors with the highest quality evidence, reporting medium effect sizes, were advanced paternal age, obstetric complications, and cannabis use. The strongest evidence among the putative antecedents was identified for motor dysfunction and low IQ.
CONCLUSIONS: More research is required that applies sound methodological practices, taking into consideration specificity for schizophrenia and possible confounding factors, to robustly identify the non-genetic risk factors and putative antecedents of schizophrenia.
Sandra L Matheson; Alana M Shepherd; Kristin R Laurens; Vaughan J Carr
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review     Date:  2011-10-13
Journal Detail:
Title:  Schizophrenia research     Volume:  133     ISSN:  1573-2509     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-04-09     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  133-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Brain Injuries
Databases, Bibliographic / statistics & numerical data
Maternal-Fetal Exchange
Obstetric Labor Complications
Outcome Assessment (Health Care)
Risk Factors
Schizophrenia / epidemiology*,  etiology*
Sex Characteristics
Sex Offenses
Substance-Related Disorders / epidemiology
Grant Support
CDF/01/015//Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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