Document Detail

A system for quantitative analysis of associative learning. Part 1. Hardware interfaces with cross-species applications.
MedLine Citation:
PMID:  7815815     Owner:  NLM     Status:  MEDLINE    
This paper describes a reliable, durable, and readily calibrated hardware interface system designed to present sensory stimuli at precise time intervals and to transduce and digitize behavioral data in classical conditioning experiments. It has been extensively tested in a 'model'-associative learning task, conditioning of eyeblink or nictitating membrane responses, but is readily adapted to other behavioral paradigms. Each system can run a pair of conditioned experimental or pseudoconditioned control subjects simultaneously, or collect data from a single subject carrying out two tasks simultaneously. The requirements of the system are defined, based around an inexpensive AT-class MS-DOS microcomputer. The interface hardware needed to present auditory tone conditioned stimuli and corneal airpuff-unconditioned stimuli to training subjects are detailed, with timing signals provided by TTL pulses generated at the digital output ports of an analog-to-digital (A/D) converter. An electronic circuit is described that provides stable inputs to the A/D converter, transducing eyeblink responses to voltage signals opto-electronically, without requiring any invasive attachment of the subject to the subject to the measuring device. The 1-piece eyeblink sensor used (selected for ease of alignment and maintenance) is also discussed. Examples of applications for classical conditioning of rabbits, rats, and human subjects are described. A companion paper describes data-acquisition and control software written as a user-friendly interface for this hardware system.
L T Thompson; J R Moyer; E Akase; J F Disterhoft
Related Documents :
24211995 - A hurst exponent estimator based on autoregressive power spectrum estimation with order...
18629035 - Utopia-user-friendly tools for operating informatics applications.
24656145 - Fast algorithms for approximate circular string matching.
23026335 - Modelling and computational fluid dynamic behaviour of a biofilter treating benzene.
24090855 - Personal networks of prisoners prior to incarceration: a comparison with the general du...
3169055 - Quantitative aspect of two-factor analysis applied to radionuclide gated cardiac studies.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  54     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-08     Completed Date:  1995-02-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  109-17     Citation Subset:  IM    
Department of Cell and Molecular Biology Northwestern University Medical School, Chicago, IL 60611.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Association Learning*
Conditioning, Classical
Electric Wiring
Equipment Design
Nictitating Membrane / physiology
Signal Processing, Computer-Assisted
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A simple and rapid method for sequencing the entire coding region of the human prion protein (PrP) g...
Next Document:  A system for quantitative analysis of associative learning. Part 2. Real-time software for MS-DOS mi...