| Maternal/congenital syphilis in a large tertiary-care urban hospital. | |
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MedLine Citation:
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PMID: 8110928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Among the women delivering a total of 9,591 infants in 1990 at Hutzel Hospital in Detroit, 148 had positive results in the rapid plasma reagin (RPR) and fluorescent treponemal antibody-absorption tests for syphilis. This group included primarily young, black, multigravid women with a history of crack cocaine use. RPR titers ranged from 1:1 to 1:256 among the 103 mothers not treated or inadequately treated for syphilis. Two mothers with very low RPR titers (1:2) delivered a stillborn infant and an infant with a reaction in the cerebrospinal fluid Venereal Disease Research Laboratory (CSF-VDRL) test, respectively. Seventy-five percent of the infants born to untreated or inadequately treated women had asymptomatic congenital syphilis. The remaining 25% were stillborn (6 infants) or had clinical features of congenital syphilis (3 infants), a reactive CSF-VDRL test (11 infants), or radiological evidence of periostitis or metaphysitis (6 infants). Abnormalities were documented in the placentas from 11 live births and one stillbirth. The resurgence of congenital syphilis highlights the need for better diagnostic tests and for studies that will determine optimal therapy for mother and infant. |
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Authors:
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M P Reyes; N Hunt; E M Ostrea; D George |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 17 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-25 Completed Date: 1994-03-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1041-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Wayne State University, Detroit, Michigan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Epidemiologic Factors Female Hospitals, Urban Humans Infant, Newborn Male Michigan / epidemiology Penicillin G Benzathine / therapeutic use Pregnancy Pregnancy Complications, Infectious / diagnosis, drug therapy, epidemiology* Pregnancy Outcome Syphilis / complications*, diagnosis, epidemiology* Syphilis Serodiagnosis Syphilis, Congenital / diagnosis, drug therapy, epidemiology* |
| Chemical | |
Reg. No./Substance:
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1538-09-6/Penicillin G Benzathine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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