| On the synthesis and characterization of N-formyl glutathione and N-acetyl glutathione. | |
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MedLine Citation:
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PMID: 8250215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of glutathione (GSH) with formic acid and acetic anhydride leads to preparation of crystalline N-formyl GSH. This is the first characterized preparation of N-formyl GSH; this product was previously erroneously thought to be N-acetyl GSH. Authentic N-acetyl GSH (crystalline) was prepared by treating GSH with acetic acid and acetic anhydride. The N-acylated derivatives were characterized by 1H NMR and mass spectroscopy. |
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Authors:
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E J Levy; M E Anderson; A Meister |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Analytical biochemistry Volume: 214 ISSN: 0003-2697 ISO Abbreviation: Anal. Biochem. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-01-05 Completed Date: 1994-01-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370535 Medline TA: Anal Biochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 135-7 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Cornell University Medical College, New York, New York 10021. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Anhydrides Formic Acids Glutathione / analogs & derivatives*, chemical synthesis Indicators and Reagents Magnetic Resonance Spectroscopy / methods Mass Spectrometry / methods |
| Grant Support | |
ID/Acronym/Agency:
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2R37 DK12034/DK/NIDDK NIH HHS; T3 2 DK07152/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetic Anhydrides; 0/Formic Acids; 0/Indicators and Reagents; 108-24-7/acetic anhydride; 28542-76-9/N-acetylglutathione; 64-18-6/formic acid; 70-18-8/Glutathione; 70239-28-0/N-formylglutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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