Document Detail

On the synthesis of bioisosters of o-benzothiazolyloxybenzoic acids and evaluation as aldose reductase inhibitors.
MedLine Citation:
PMID:  16143958     Owner:  NLM     Status:  MEDLINE    
In continuation of our attempts to develop novel aldose reductase inhibitors (ARIs), a number of compounds characterized by bioisosteric replacement of pharmacophors were prepared. On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipophilic substituent was modified. The results of the biological evaluation of these derivatives enabled us to gain insight into structural features critical for the aldose reductase inhibition.
Dietmar Rakowitz; Patric Muigg; Nicole Schröder; Barbara Matuszczak
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archiv der Pharmazie     Volume:  338     ISSN:  0365-6233     ISO Abbreviation:  Arch. Pharm. (Weinheim)     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-19     Completed Date:  2005-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330167     Medline TA:  Arch Pharm (Weinheim)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  419-26     Citation Subset:  IM    
Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.
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MeSH Terms
Aldehyde Reductase / antagonists & inhibitors*
Benzoic Acids / chemical synthesis*,  chemistry
Enzyme Inhibitors / chemical synthesis*,  chemistry
Lens, Crystalline / enzymology
Molecular Structure
Structure-Activity Relationship
Thiazoles / chemical synthesis*,  chemistry
Reg. No./Substance:
0/Benzoic Acids; 0/Enzyme Inhibitors; 0/Thiazoles; EC Reductase

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