| On the synthesis of bioisosters of o-benzothiazolyloxybenzoic acids and evaluation as aldose reductase inhibitors. | |
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MedLine Citation:
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PMID: 16143958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In continuation of our attempts to develop novel aldose reductase inhibitors (ARIs), a number of compounds characterized by bioisosteric replacement of pharmacophors were prepared. On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipophilic substituent was modified. The results of the biological evaluation of these derivatives enabled us to gain insight into structural features critical for the aldose reductase inhibition. |
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Authors:
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Dietmar Rakowitz; Patric Muigg; Nicole Schröder; Barbara Matuszczak |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Archiv der Pharmazie Volume: 338 ISSN: 0365-6233 ISO Abbreviation: Arch. Pharm. (Weinheim) Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-19 Completed Date: 2005-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0330167 Medline TA: Arch Pharm (Weinheim) Country: Germany |
Other Details:
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Languages: eng Pagination: 419-26 Citation Subset: IM |
Affiliation:
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Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehyde Reductase
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antagonists & inhibitors* Animals Benzoic Acids / chemical synthesis*, chemistry Cattle Enzyme Inhibitors / chemical synthesis*, chemistry Lens, Crystalline / enzymology Molecular Structure Structure-Activity Relationship Thiazoles / chemical synthesis*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Benzoic Acids; 0/Enzyme Inhibitors; 0/Thiazoles; EC 1.1.1.21/Aldehyde Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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