Document Detail


The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus.
MedLine Citation:
PMID:  14510617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis and characterization of the conopeptide, SO-3, originally derived from Conus striatus is reported. It contains 25 amino acid residues and three disulfide bridges and manifests 72% sequence identity with MVIIA, an N-type Ca2+ channel inhibitor of high analgesic activity. We evaluated SO-3 in several mouse models of pain. The results indicate that SO-3 is a potent, nonaddictive, analgesic agent.
Authors:
Qiuyun Dai; Fengyun Liu; Yanrong Zhou; Baisong Lu; Fang Yu; Peitang Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  66     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-26     Completed Date:  2004-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1276-9     Citation Subset:  IM    
Affiliation:
Institute of Biotechnology, Beijing 100071, People's Republic of China. qdai@nd.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Analgesics / chemistry,  isolation & purification*,  pharmacology*
Animals
Calcium Channel Blockers / chemistry,  isolation & purification*,  pharmacology*
Conotoxins / chemistry,  isolation & purification*,  pharmacology*
Goldfish
Mice
Models, Animal
Molecular Sequence Data
Pain
Peptides / chemistry,  isolation & purification*,  pharmacology*
Protein Folding
Rats
Snails / chemistry*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Calcium Channel Blockers; 0/Conotoxins; 0/Peptides; 0/SO-3 conopeptide, Conus striatus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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