| The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline. | |
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MedLine Citation:
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PMID: 10987419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The potent neuroexcitatory activity of kainoid amino acids in the mammalian CNS places new analogues in high demand as tools for neuropharmacological research. A range of 4-arylsulfanyl-substituted kainoids has been synthesised in a parallel fashion via mesylate displacement by a number of aromatic and heteroaromatic thiolates upon (2S,3S,4R)-1-benzoyl-3-tert-butoxycarbonylmethyl-4-methanesulfo nyloxy pyrrolidine-2-carboxylic acid methyl ester 8, which is obtainable in eight steps from trans-4-hydroxy-L-proline 5. |
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Authors:
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J E Baldwin; G J Pritchard; D S Williamson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 10 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2001-01-04 Completed Date: 2001-01-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1927-9 Citation Subset: IM |
Affiliation:
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The Dyson Perrins Laboratory, University of Oxford, UK. jack.baldwin@chem.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Hydroxyproline Kainic Acid / chemical synthesis* Receptors, Kainic Acid / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Kainic Acid; 487-79-6/Kainic Acid; 51-35-4/Hydroxyproline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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