Document Detail


The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline.
MedLine Citation:
PMID:  10987419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potent neuroexcitatory activity of kainoid amino acids in the mammalian CNS places new analogues in high demand as tools for neuropharmacological research. A range of 4-arylsulfanyl-substituted kainoids has been synthesised in a parallel fashion via mesylate displacement by a number of aromatic and heteroaromatic thiolates upon (2S,3S,4R)-1-benzoyl-3-tert-butoxycarbonylmethyl-4-methanesulfo nyloxy pyrrolidine-2-carboxylic acid methyl ester 8, which is obtainable in eight steps from trans-4-hydroxy-L-proline 5.
Authors:
J E Baldwin; G J Pritchard; D S Williamson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  10     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-01-04     Completed Date:  2001-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1927-9     Citation Subset:  IM    
Affiliation:
The Dyson Perrins Laboratory, University of Oxford, UK. jack.baldwin@chem.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Hydroxyproline
Kainic Acid / chemical synthesis*
Receptors, Kainic Acid / drug effects
Chemical
Reg. No./Substance:
0/Receptors, Kainic Acid; 487-79-6/Kainic Acid; 51-35-4/Hydroxyproline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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