Document Detail

The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline.
MedLine Citation:
PMID:  10987419     Owner:  NLM     Status:  MEDLINE    
The potent neuroexcitatory activity of kainoid amino acids in the mammalian CNS places new analogues in high demand as tools for neuropharmacological research. A range of 4-arylsulfanyl-substituted kainoids has been synthesised in a parallel fashion via mesylate displacement by a number of aromatic and heteroaromatic thiolates upon (2S,3S,4R)-1-benzoyl-3-tert-butoxycarbonylmethyl-4-methanesulfo nyloxy pyrrolidine-2-carboxylic acid methyl ester 8, which is obtainable in eight steps from trans-4-hydroxy-L-proline 5.
J E Baldwin; G J Pritchard; D S Williamson
Related Documents :
3279209 - Synthesis and anticandidal properties of polyoxin l analogues containing alpha-amino fa...
11416029 - Enhanced activity in parathyroid hormone-(1-14) and -(1-11): novel peptides for probing...
12932899 - A structure-activity study of nociceptin-(1-13)-peptide amide. synthesis of analogues s...
19429429 - Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic...
15387649 - Nodulisporic acids d-f: structure, biological activities, and biogenetic relationships.
6199209 - Mitogenic and polyclonal b cell activation activities of synthetic lipid a analogues.
19460009 - Antibacterial properties of soap containing some fatty acid esters.
15782909 - Direct determination of optimal amino acid intake for maintenance and growth in broilers.
7236659 - Glutathione-dependent inhibition of lipid peroxidation by a soluble, heat-labile factor...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  10     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-01-04     Completed Date:  2001-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1927-9     Citation Subset:  IM    
The Dyson Perrins Laboratory, University of Oxford, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Kainic Acid / chemical synthesis*
Receptors, Kainic Acid / drug effects
Reg. No./Substance:
0/Receptors, Kainic Acid; 487-79-6/Kainic Acid; 51-35-4/Hydroxyproline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  5-HETE congeners as modulators of cell proliferation.
Next Document:  Solid-phase synthesis of 4-substituted imidazoles using a scaffold approach.