Document Detail


The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis.
MedLine Citation:
PMID:  18203762     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A). METHODS: Synovial membranes from patients with femur fracture, avascular necrosis of the femur, plica syndrome, and meniscus and/or ligament injury (n = 23); rheumatoid arthritis (n = 28); osteoarthritis (OA; n = 25); and from normal controls (n = 10) were assessed by light microscopy, a histological synovitis score, immunostaining for CD3, CD20, CD38, CD68, Ki-67 and von Willebrand factor, and with an immunohistochemical inflammation score. RESULTS: Orth. A histology varied between normal and markedly inflamed. Predominant abnormalities were mild lining hyperplasia, scattered inflammatory cells and small perivascular infiltrates. The synovitis score classified Orth. A as "mild synovitis". Inflammatory cells occurred frequently: CD68+ cells in 100% of Orth. A specimens; CD3+, 91%; CD38+, 70%; and CD20+, 39%. Orth. A had 36% greater lining thickness (p = 0.04), 40% higher vascular density (p = 0.009) and 51.3-fold higher CD38+ cell density (p = 0.02) than normal controls; and 60% fewer subintimal Ki-67+ cells (p = 0.003), 42% fewer CD68+ lining cells (p<0.01) and 40% fewer subintimal CD68+ cells (p<0.01) than OA. The immunohistochemical inflammation score was 2.2-fold higher in Orth. A than in controls (p = 0.048) and similar to OA, with three Orth. A specimens showing marked inflammation. CONCLUSIONS: Synovial membranes from "non-inflammatory" arthropathies featured neovascularisation and inflammation intermediate between normal and OA synovium. These results expand previous findings that mechanical joint injury may lead to a mild-to-moderate synovitis.
Authors:
F Pessler; L Dai; C Diaz-Torne; C Gomez-Vaquero; M E Paessler; D-H Zheng; E Einhorn; U Range; C Scanzello; H R Schumacher
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-01-18
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  67     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1184-7     Citation Subset:  IM    
Affiliation:
The Children's Hospital of Philadelphia, Division of Rheumatology, Philadelphia, USA. frank.pessler@uniklinikum-dresden.de
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD / analysis
Antigens, CD20 / analysis
Antigens, CD3 / analysis
Antigens, CD38 / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Arthritis, Rheumatoid / immunology
Biological Markers / analysis
Case-Control Studies
Femoral Fractures / complications,  immunology
Femur / pathology
Humans
Immunohistochemistry
Joints / injuries*
Ligaments / injuries
Necrosis
Osteoarthritis / complications,  immunology
Statistics, Nonparametric
Synovial Membrane / chemistry*
Synovitis / etiology,  immunology*
von Willebrand Factor / analysis
Grant Support
ID/Acronym/Agency:
T32-AR 007442/AR/NIAMS NIH HHS; T32-CA 09140/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD20; 0/Antigens, CD3; 0/Antigens, Differentiation, Myelomonocytic; 0/Biological Markers; 0/CD68 antigen, human; 0/von Willebrand Factor; EC 3.2.2.5/Antigens, CD38

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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