Document Detail

The syndrome of pseudotumour cerebri and idiopathic intracranial hypertension.
MedLine Citation:
PMID:  21150597     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Idiopathic intracranial hypertension (IIH) is a condition in which raised intracranial pressure is associated with a high body mass index, and in those societies in which the prevalence of obesity is increasing the disorder is of increasing importance. It is one cause of the syndrome of pseudotumour cerebri but the cause and the link with a rise in body weight are not understood. Furthermore the treatment of the more severe, sight-threatening cases is controversial.
RECENT FINDINGS: A major theme in recent years has been an attempt to identify the underlying mechanism of IIH. Some theories - such as the dural sinus stenosis theory - seem to ignore the relationship with weight gain; others have proposed a direct link between obesity and raised intracranial pressure through a specific fat distribution in the body; others through the production of lipokines; and yet others have suggested a converse causation with raised intracranial pressure giving rise to obesity. Uncontrolled case series continue to demonstrate the success of interventions such as cerebrospinal fluid diversion procedures, venous sinus stenting and bariatric surgery but there are no level 1 clinical trials.
SUMMARY: Interest in IIH is increasing and currently generating numerous studies but there is no consensus view on either cause or management.
Clare Fraser; Gordon T Plant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  24     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-30     Completed Date:  2011-04-14     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Moorfields Eye Hospital, City Road, London, UK.
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MeSH Terms
Acetazolamide / therapeutic use
Body Mass Index
Carbonic Anhydrase Inhibitors / therapeutic use
Constriction, Pathologic
Intracranial Hypertension / diagnosis,  drug therapy,  physiopathology*,  surgery
Magnetic Resonance Imaging
Obesity / complications
Pseudotumor Cerebri / diagnosis,  drug therapy,  physiopathology*,  surgery
Weight Loss
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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