Document Detail

Sjögren's syndrome and pregnancy.
MedLine Citation:
PMID:  1780917     Owner:  NLM     Status:  MEDLINE    
We analyzed 117 histories of pregnancy obtained from 40 female patients with Sjögren's syndrome (SS) including 13 patients with primary SS and 27 patients with secondary SS. The frequency of spontaneous abortions did not differ in the 40 patients and those with primary SS compared with 129 healthy women. However, both spontaneous abortions and premature deliveries were significantly more frequent in the SS patients with systemic lupus erythematosus (SLE). Anti-SS-A and anti-SS-B antibodies were not associated with the outcomes of pregnancy although spontaneous abortions were more frequent in secondary SS patients with false positive serological tests for syphilis, anti-erythrocyte antibodies, thrombocytopenia or prolonged activated partial thromboplastin time. Neither congenital anomalies nor connective tissue disease was found in the 77 neonates of the patients. We concluded that SS does not influence the outcome of pregnancy except in patients with SLE or those with serological and hematological abnormalities related to lupus anticoagulants or antiphospholipid antibodies.
M Takaya; Y Ichikawa; H Shimizu; M Uchiyama; J Moriuchi; S Arimori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tokai journal of experimental and clinical medicine     Volume:  16     ISSN:  0385-0005     ISO Abbreviation:  Tokai J. Exp. Clin. Med.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7704186     Medline TA:  Tokai J Exp Clin Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Abortion, Spontaneous / etiology
Infant, Newborn
Lupus Coagulation Inhibitor / blood
Lupus Erythematosus, Systemic / complications
Obstetric Labor, Premature / etiology
Pregnancy Complications / etiology*
Pregnancy Outcome
Retrospective Studies
Sjogren's Syndrome / blood,  complications*,  immunology
Thrombocytopenia / complications
Reg. No./Substance:
0/Lupus Coagulation Inhibitor

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