Document Detail

Sjögren's syndrome of the oral cavity. Review and update.
MedLine Citation:
PMID:  19300364     Owner:  NLM     Status:  MEDLINE    
Sjögren's syndrome is one of the most frequent autoimmune diseases. It is a chronic and systemic disorder predominantly found in women, and is characterized by the appearance of a lymphocytic inflammatory infiltrate, with dryness of the oral cavity and eyes, secondary to involvement of the salivary and lacrimal glands. The underlying causal mechanism involves a number of factors and has not been clearly established, though an autoimmune response is known to be triggered, with the accumulation of immune complexes in the gland acini that interfere with gland function. In the oral cavity, xerostomia or hyposialia is the most disabling manifestation for patients, and is accompanied by rapidly progressing caries, candidiasis and an important worsening of buccodental health. The most important complication is a 44-fold increase in the risk of developing non-Hodgkin lymphoma, compared with the general population. The treatment of Sjögren's syndrome is limited to symptomatic management, and involves the use of solutions to replace salivary secretion and afford a measure of hydration, cholinergic agents such as pilocarpine to stimulate the unaffected gland tissue and, recently, the administration of substances that act against surface antigens of the B lymphocytes, such as anti-CD20 and anti-CD22 antibodies. The present study provides an update on this disease, placing special emphasis on its odontologic implications.
Maria Margaix-Muñoz; José V Bagán; Rafael Poveda; Yolanda Jiménez; Gracia Sarrión
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-07-01
Journal Detail:
Title:  Medicina oral, patología oral y cirugía bucal     Volume:  14     ISSN:  1698-6946     ISO Abbreviation:  Med Oral Patol Oral Cir Bucal     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-10-01     Revised Date:  2009-12-11    
Medline Journal Info:
Nlm Unique ID:  101231694     Medline TA:  Med Oral Patol Oral Cir Bucal     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  E325-30     Citation Subset:  D; IM    
Servicio de Estomatología del Hospital General Universitario de Valencia, Universidad de Valencia, Spain.
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MeSH Terms
Mouth Diseases* / diagnosis,  therapy
Sjogren's Syndrome* / diagnosis,  therapy

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