Document Detail

The syndrome of inappropriate antidiuretic hormone secretion as a cause of hyponatremia in cystic fibrosis.
MedLine Citation:
PMID:  839369     Owner:  NLM     Status:  MEDLINE    
The syndrome of inappropriate secretion of antidiuretic hormone was observed in two patients with cystic fibrosis during acute exacerbation of chronic pulmonary disease. It was diagnosed by the accepted clinical and laboratory criteria and confirmed in one case by values for immunoreactive vasopressin that were inappropriately high for plasma osmolality. The severe hyponatremia was corrected by fluid restriction, alone or combined with intravenous treatment with diuretic and hypertonic saline solution. In addition, there was simultaneous therapy of the pulmonary disease. SIADH thus must be added to salt loss as a cause of hyponatremia in CF, and may be more common than realized in patients with CF and severe pulmonary disease.
L F Cohen; P A di Sant'Agnese; A Taylor; J R Gill
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  90     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-04-30     Completed Date:  1977-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  574-8     Citation Subset:  AIM; IM    
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MeSH Terms
Cystic Fibrosis / complications,  metabolism*
Hyponatremia / etiology*
Vasopressins / secretion*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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