Document Detail

The syndrome of hyperostosis and hyperphosphatemia.
MedLine Citation:
PMID:  6273518     Owner:  NLM     Status:  MEDLINE    
Six children, five girls and one boy, presented with recurrent episodes of swelling, pain, and tenderness of the long bones. On roentgenographic examination all had cortical hyperostosis of the affected areas. Serum phosphate concentration was persistently elevated, and calcium values were normal. Bone biopsy and histologic examination in three patients revealed periosteal new bone formation. The Ellsworth-Howard test was performed on three patients; all had a normal phosphaturic response and an increase in urinary c'AMP to exogenous PTH. The EDTA test, performed on one patient, demonstrated significant phosphaturic response, but a minimal drop in serum phosphate concentration. These findings suggest that the association of cortical hyperostosis and hyperphosphatemia is a distinct clinical entity, and that hyperphosphatemia results from decreased renal excretion of phosphate.
M A Mikati; R E Melhem; S S Najjar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  99     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  900-4     Citation Subset:  AIM; IM    
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MeSH Terms
Calcium / blood
Child, Preschool
Cyclic AMP / urine
Edetic Acid / diagnostic use
Hyperostosis, Cortical, Congenital / complications*
Parathyroid Hormone / blood
Phosphates / blood*,  urine
Reg. No./Substance:
0/Parathyroid Hormone; 0/Phosphates; 60-00-4/Edetic Acid; 60-92-4/Cyclic AMP; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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