Document Detail


The syndrome of food-cobalamin malabsorption revisited in a department of internal medicine. A monocentric cohort study of 80 patients.
MedLine Citation:
PMID:  12919836     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: To date, only case reports or small studies have documented the syndrome of food-cobalamin malabsorption in specific populations of patients or situations. In this paper, we present the data from 80 unselected patients with cobalamin deficiency related to food-cobalamin malabsorption. METHODS: We studied 80 patients with well-established food-cobalamin malabsorption who were extracted from an observational cohort study (1995-2000) of 127 consecutive patients with cobalamin deficiency and who were followed in a department of internal medicine. RESULTS: The median age of patients was 66 years and the female to male ratio was 1.2. The mean hemoglobin level was 113+/-27 g/l (range 32-159 g/l) and the mean erythrocyte cell volume was 95.4+/-12.3 fl (range 55-140 fl). Mean serum vitamin B12 and homocysteine levels were 153+/-74 pg/ml (range 35-200 pg/ml) and 20.6+/-15.7 μmol/l (range 8-97 μmol/l), respectively. The main clinical findings noted were peripheral neuropathy (46.2%), stroke (12.5%), confusion or dementia (10%), asthenia (18.7%), leg edema (11.2%), and digestive disorders (7.5%). The commonest associated conditions were atrophic gastritis (39%) with evidence of Helicobacter pylori infection (12.2%) and alcohol abuse (13.7%). Three patients had Sjögren's syndrome and one had systemic sclerosis. Ten percent of all patients were on long-term metformin (10%) and 7.5% on acid-suppressive drugs. Correction of the serum vitamin B12 levels and hematological abnormalities was achieved equally well in all patients treated with either intramuscular or oral crystalline cyanocobalamin. CONCLUSION: This study suggests that food-cobalamin malabsorption may be the leading cause of vitamin B12 deficiency in adults. As other studies have also reported, the condition is often associated with neuro-psychiatric findings and with several other conditions. Oral and parenteral cobalamin appear to be equally effective in correcting serum B12 levels and hematological abnormalities and, in many cases, they also relieve symptoms.
Authors:
Emmanuel Andrès; Anne Elisabeth Perrin; Christine Demangeat; Jean Emmanuel Kurtz; Stéphane Vinzio; Fabienne Grunenberger; Bernard Goichot; Jean Louis Schlienger
Related Documents :
8110846 - Dietary habits and the risk of stomach cancer: a comparison study of patients with and ...
10694776 - Ten-year trends in vitamin and mineral intake from fortified food in german children an...
8946266 - Antioxidants and coronary heart disease: observational studies.
15479016 - Distribution of ascorbic acid in potato tubers and in home-processed and commercial pot...
10421676 - On the evolution of multicelluarity and eusociality.
17209226 - Pilot study of indoor radon in greek workplaces.
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  European journal of internal medicine     Volume:  14     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-Aug-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  221-226     Citation Subset:  -    
Affiliation:
Department of Internal Medicine and Nutrition, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sarcoidosis: benefits of a multidisciplinary approach.
Next Document:  Risk factors for metastatic infection in patients with Staphylococcus aureus bacteremia with and wit...