| The syndrome of delayed post-hypoxic leukoencephalopathy. | |
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MedLine Citation:
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PMID: 20166270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Delayed post-hypoxic leukoencephalopathy (DPHL) is a demyelinating syndrome characterized by acute onset of neuropsychiatric symptoms days to weeks following apparent recovery from coma after a period of prolonged cerebral hypo-oxygenation. It is diagnosed, after excluding other potential causes of delirium, with a clinical history of carbon monoxide poisoning, narcotic overdose, myocardial infarction, or another global cerebral hypoxic event. The diagnosis can be supported by neuroimaging evidence of diffuse hemispheric demyelination sparing cerebellar and brainstem tracts, or by an elevated cerebrospinal fluid myelin basic protein. Standard or hyperbaric oxygen following CO poisoning may reduce the likelihood of DPHL or other neurologic sequelae. Bed rest and avoidance of stressful procedures for the first 10 days following any prolonged hypoxic event may also lower the risk. Gradual recovery over a 3 to 12 month period is common, but impaired attention or executive function, parkinsonism, or corticospinal tract signs can persist. Stimulants, amantadine or levodopa may be considered for lasting cognitive or parkinsonian symptoms. Anticipation and recognition of DPHL should lead to earlier and more appropriate utilization of health care services. |
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Authors:
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David Shprecher; Lahar Mehta |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: NeuroRehabilitation Volume: 26 ISSN: 1878-6448 ISO Abbreviation: NeuroRehabilitation Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-18 Completed Date: 2010-04-26 Revised Date: 2010-12-30 |
Medline Journal Info:
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Nlm Unique ID: 9113791 Medline TA: NeuroRehabilitation Country: Netherlands |
Other Details:
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Languages: eng Pagination: 65-72 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Utah, Salt Lake City, UT 84108, USA. David.Shprecher@hsc.utah.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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complications*,
diagnosis,
epidemiology Cognition Disorders / etiology, therapy Diagnosis, Differential Disease Progression Humans Leukoencephalopathies / diagnosis, epidemiology, etiology*, therapy |
| Grant Support | |
ID/Acronym/Agency:
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L30 NS063416-01/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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