Document Detail

A syndrome characterized by nodular eosinophilic infiltration of the skin and immunoglobulin isotype imbalance.
MedLine Citation:
PMID:  1999546     Owner:  NLM     Status:  MEDLINE    
A 9-year-old boy had recurrent acute, plaquelike, nodular infiltrations with overlying vesicles and bullae of the face and right hand. Histologically, the lesions consisted of a perivascular and periadnexal lymphohistiocytic infiltrate with many eosinophils. The lesions responded to dapsone therapy. Laboratory studies revealed blood eosinophilia, hyperimmunoglobulinemias E and G4, and hypoimmunoglobulinemias M and G1-3, which normalized after treatment. The patient's immune deviation is consistent with a transient imbalance of lymphokine production in helper T cells.
C Hauser; J H Saurat
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  24     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-04-10     Completed Date:  1991-04-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  352-5     Citation Subset:  IM    
Department of Dermatology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
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MeSH Terms
Dysgammaglobulinemia / complications*
Eosinophilia / complications*
Hypergammaglobulinemia / complications*
IgG Deficiency
Immunoglobulin E
Immunoglobulin M / deficiency
Skin / pathology
Skin Diseases / complications,  immunology,  pathology*
Reg. No./Substance:
0/Immunoglobulin M; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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