| The syndrome of arthrogryposis multiplex congenita. | |
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MedLine Citation:
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PMID: 5173748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arthrogryposis Multiplex Congenita (AMC) is a syndrome characterized by confenital rigidity or "clubbing" of multiple joints. Soft-tissue ankylosis restricts the motion of the joints, which are fixed in postures dictated by the position of the embryo during development. The joint malformations result from relatively brief immobilization of the developing embryo due to a variety of factors. This concept of pathogenesis derives support from the experimental reproduction of AMC in chick embryos paralyzed by a variety of pharmacologic agents. In man, prenatal disorders which are capable of immolilizing the embryo give rise to AMC. These disorders may affect the brain, spinal cord, peripheral nerves, or muscles. Various mechanical factors that restrict the embryo's movements can also produce joint malformations. Thus, AMC should be regarded as a syndrome of articular malformations which may stem from many different causes rather than as a disease entity. |
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Authors:
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D B Drachman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Birth defects original article series Volume: 7 ISSN: 0547-6844 ISO Abbreviation: Birth Defects Orig. Artic. Ser. Publication Date: 1971 Feb |
Date Detail:
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Created Date: 1975-05-27 Completed Date: 1975-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0003403 Medline TA: Birth Defects Orig Artic Ser Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 90-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arthrogryposis* / chemically induced, etiology, pathology Chick Embryo Clubfoot / etiology Demyelinating Diseases / complications Disease Models, Animal Female Fetal Diseases / complications Humans Infant, Newborn Migraine Disorders / complications Motor Neurons / pathology Muscles / pathology Muscular Atrophy / genetics Muscular Dystrophies / complications Nerve Degeneration Neuromuscular Blocking Agents Ophthalmoplegia / complications Paralysis / chemically induced, complications Periodicity Pregnancy Pregnancy Complications Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Neuromuscular Blocking Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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