Document Detail

The syndrome of amniotic fluid embolism: a potential contribution of bradykinin.
MedLine Citation:
PMID:  16202747     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Amniotic fluid embolism is a potentially fatal complication of pregnancy; although several hypotheses have been formulated, the pathophysiology of this condition is not well known. An exaggerated release of bradykinin, which is activated by products of the amniotic fluid that enter the maternal circulation, could explain the symptoms that are present in amniotic fluid embolism. The objective of this study was to assess whether bradykinin is involved in amniotic fluid embolism. STUDY DESIGN: The plasma bradykinin-generating capacity was measured serially in a patient who experienced amniotic fluid embolism. RESULTS: The plasma bradykinin-generating capacity was found to be very low at the time of the initial clinical manifestations, which were characterized by severe hypotension, cardiorespiratory arrest, and coagulopathy. CONCLUSION: This study suggests a potential role for bradykinin release in the pathophysiology of amniotic fluid embolism.
Josée Robillard; France Gauvin; Giuseppe Molinaro; Line Leduc; Albert Adam; Georges E Rivard
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  193     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2006-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1508-12     Citation Subset:  AIM; IM    
Faculté de Pharmacie, Université de Montréal, Montreal, Quebec, Canada.
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MeSH Terms
Bradykinin / blood*,  physiology
Embolism, Amniotic Fluid / blood*,  etiology
Reg. No./Substance:

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