Document Detail


Sézary syndrome: Immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC).
MedLine Citation:
PMID:  21145619     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Sézary syndrome (SS) has a poor prognosis and few guidelines for optimizing therapy. The US Cutaneous Lymphoma Consortium, to improve clinical care of patients with SS and encourage controlled clinical trials of promising treatments, undertook a review of the published literature on therapeutic options for SS. An overview of the immunopathogenesis and standardized review of potential current treatment options for SS including metabolism, mechanism of action, overall efficacy in mycosis fungoides and SS, and common or concerning adverse effects is first discussed. The specific efficacy of each treatment for SS, both as monotherapy and combination therapy, is then reported using standardized criteria for both SS and response to therapy with the type of study defined by a modification of the US Preventive Services guidelines for evidence-based medicine. Finally, guidelines for the treatment of SS and suggestions for adjuvant treatment are noted.
Authors:
Elise A Olsen; Alain H Rook; John Zic; Youn Kim; Pierluigi Porcu; Christiane Querfeld; Gary Wood; Marie-France Demierre; Mark Pittelkow; Lynn D Wilson; Lauren Pinter-Brown; Ranjana Advani; Sareeta Parker; Ellen J Kim; Jacqueline M Junkins-Hopkins; Francine Foss; Patrick Cacchio; Madeleine Duvic
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Publication Detail:
Type:  Journal Article     Date:  2010-12-09
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  64     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-404     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Affiliation:
Duke University Medical Center, Durham, North Carolina.
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