Document Detail

The syndrome of 5-fluorouracil cardiotoxicity. An elusive cardiopathy.
MedLine Citation:
PMID:  8422644     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A case of reversible cardiogenic shock linked to 5-fluorouracil (5-FU) was observed. Recognizing the increasing use of 5-FU, the authors tried to map this syndrome. METHODS: They reviewed 134 additional case reports, retrieved information from literature searches, focused on clinical features, and discussed possible pathophysiologic findings and prevention of this syndrome. RESULTS: Although angina and electrocardiographic changes were common and reproducible (approximately 90% each), coronary artery disease was found in a few patients. A total of 33 patients had severe left ventricular dysfunction, 28 without evidence of myocardial infarction. The symptoms were responsive to conservative management (90%). CONCLUSIONS: Cardiac toxicity is a little known complication of 5-FU therapy, with an unknown but significant incidence. It is highly treatable.
N C Robben; A W Pippas; J O Moore
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer     Volume:  71     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-23     Completed Date:  1993-02-23     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  493-509     Citation Subset:  AIM; IM    
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Fluorouracil / administration & dosage,  adverse effects*
Heart Diseases / chemically induced*
Middle Aged
Pyrimidines / metabolism
Reg. No./Substance:
0/Pyrimidines; 289-95-2/pyrimidine; 51-21-8/Fluorouracil
Comment In:
Cancer. 1994 Apr 1;73(7):2001-2   [PMID:  8137229 ]

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