Document Detail

Is the sympathetic nervous system altered in children with familial history of arterial hypertension?
MedLine Citation:
PMID:  3416329     Owner:  NLM     Status:  MEDLINE    
The sympathetic nervous system has been investigated in 42 children with family history of arterial hypertension and 68 children of the same age without hypertensive relatives. Pressure responses to mental arithmetic and to isometric handgrip stress were measured in both groups, along with 24 h catecholamine excretion. Resting blood pressure and heart rate did not show any difference between groups. The increase in diastolic pressure during the mental arithmetic exercise was, however, significantly greater in children with family history of hypertension. A sharp increase in blood pressure and heart rate was observed during isometric handgrip in both groups without any significant difference. Twenty-four hour catecholamine urinary excretion was significantly higher in the group with family history of hypertension (31 +/- 15 vs. 23 +/- 13 micrograms/24 h; p less than 0.05). These results seem to indicate that an initial impairment of the sympathetic activity is already detectable in young offspring of hypertensive patients.
L A Ferrara; T S Moscato; N Pisanti; T Marotta; V Krogh; D Capone; M Mancini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  75     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1988  
Date Detail:
Created Date:  1988-10-19     Completed Date:  1988-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  200-5     Citation Subset:  IM    
Institute of Internal Medicine and Metabolic Diseases, University of Naples, Italy.
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MeSH Terms
Blood Pressure
Catecholamines / urine
Heart Rate
Hypertension / genetics*,  physiopathology
Isometric Contraction
Stress, Psychological / physiopathology
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:

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