Document Detail


The switch from fetal to adult erythropoiesis.
MedLine Citation:
PMID:  10986626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The story of the developmental changes in erythropoiesis is the history of oxygenation in the developing organism. The individual components of the switch from embryonic to adult erythropoiesis are developmentally regulated, and their interaction with one another is complex. Basic defects, such as absence of Epo production, lead to early embryonic or fetal death. Other defects, such as abnormalities in the switch from the fetal to adult erythropoiesis, are less catastrophic but result in hematologic abnormalities. Understanding the many aspects of the switch from embryonic to fetal to adult erythropoiesis can lead to an improved awareness of many of the problems typical of preterm infants, inborn errors resulting in hematologic diseases, and aspects important for transplantation medicine.
Authors:
C Dame; S E Juul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  27     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-26     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Children's Hospital, University of Bonn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging / physiology*
Embryonic and Fetal Development / physiology
Erythropoiesis / physiology*
Fetus / physiology*
Gene Expression Regulation, Developmental
Hemoglobins / chemistry,  genetics,  metabolism
Humans
Grant Support
ID/Acronym/Agency:
RR-00083/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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