Document Detail


A swine model for studying intestinal circulation of the newborn.
MedLine Citation:
PMID:  2709269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe a newborn swine model to study intestinal hemodynamics of developing mammals. The preparation is designed to allow measurement of perfusion pressure and blood flow in an isolated segment of ileum under controlled conditions. Piglets in this study had a mean blood pressure of 65 +/- 14 (SD) mm Hg and mean intestinal blood flow of 80 +/- 20 (SD) ml/100 g/min at an average age and weight of 6.1 +/- 3 (SD) days and 1,718 +/- 427 (SD) g (n = 21). Experiments were performed to evaluate the effects of common physiologic perturbations: (a) Increased venous pressure caused a decrease in blood flow proportional to the lower perfusion pressure, but the relative change in vascular resistance was greater than the blood flow change. This effect, suggestive of a myogenic response, was significantly greater at a venous pressure increase of 20 cm of water over baseline compared with an increase of 10 cm water. (b) Gradual decrease in mesenteric artery blood pressure by clamping resulted in proportional decreases in blood flow. The calculated peripheral vascular resistance remained constant at blood pressure greater than 50 mm Hg and then increased as blood pressure decreased. (c) Stimulation of periarterial, postganglionic nerves surrounding the mesenteric artery produced a characteristic initial vasoconstriction followed by "autoregulatory escape." Frequency response tests using trains of stimulation of 6 ms and 12 V demonstrated responses starting at 2 Hz and maximal at 16 Hz. We suggest that this model should be applicable to a number of physiologic studies including assessment of water and nutrient flux in the intestine concomitant to changes in the circulation.
Authors:
S A Bustamante; O Lundgren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  8     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  376-83     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Arizona, Tucson.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Blood Circulation*
Blood Flow Velocity
Blood Pressure Determination / veterinary*
Hemodynamics
Intestines / blood supply*
Models, Biological
Swine / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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