Document Detail

A suspected case of ornithine transcarbamylase deficiency in a cat.
MedLine Citation:
PMID:  15240946     Owner:  NLM     Status:  MEDLINE    
An 18 month-old, intact female American Shorthair cat was presented for evaluation of stunted growth and postprandial depression. Fasting serum ammonia and serum bile acid concentrations were above reference ranges at 396 microg/dl and 6.5 micromol/ l and their postprandial concentrations were 785 microg/dl and 9.5 micromol/l, respectively. The initial tentative diagnosis of a portosystemic shunt was excluded by mesenteric portography and histopathology of the liver. The cat was then suspected of a urea cycle enzyme deficiency and its urine was analyzed by gas chromatography-mass spectrometry. A presumptive diagnosis of ornithine transcarbamylase deficiency was made on the basis of the detection of orotic acid and uracil.
Tsukimi Washizu; Makoto Washizu; Chunhua Zhang; Isamu Matsumoto; Masaki Sawamura; Takashi Suzuki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  66     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  701-3     Citation Subset:  IM    
Department of Clinical Pathology, Nippon Veterinary and Animal Science University, Tokyo, Japan.
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MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Bile Acids and Salts / blood
Cat Diseases / diagnosis,  enzymology*
Gas Chromatography-Mass Spectrometry / veterinary
Hyperammonemia / veterinary
Ornithine Carbamoyltransferase / biosynthesis,  metabolism
Ornithine Carbamoyltransferase Deficiency Disease / diagnosis,  veterinary*
Orotic Acid / urine
Portasystemic Shunt, Surgical
Portography / veterinary
Postprandial Period
Uracil / urine
Urine / chemistry
Reg. No./Substance:
0/Bile Acids and Salts; 65-86-1/Orotic Acid; 66-22-8/Uracil; EC Carbamoyltransferase; EC Aminotransferases; EC Transaminase

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