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The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis.
MedLine Citation:
PMID:  21821849     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aims A substantial proportion of patients with heart failure have preserved left ventricular ejection fraction (HF-PEF). Previous studies have reported mixed results whether survival is similar to those patients with heart failure and reduced EF (HF-REF). Methods and results We compared survival in patients with HF-PEF with that in patients with HF-REF in a meta-analysis using individual patient data. Preserved EF was defined as an EF ≥ 50%. The 31 studies included 41 972 patients: 10 347 with HF-PEF and 31 625 with HF-REF. Compared with patients with HF-REF, those with HF-PEF were older (mean age 71 vs. 66 years), were more often women (50 vs. 28%), and have a history of hypertension (51 vs. 41%). Ischaemic aetiology was less common (43 vs. 59%) in patients with HF-PEF. There were 121 [95% confidence interval (CI): 117, 126] deaths per 1000 patient-years in those with HF-PEF and 141 (95% CI: 138, 144) deaths per 1000 patient-years in those with HF-REF. Patients with HF-PEF had lower mortality than those with HF-REF (adjusted for age, gender, aetiology, and history of hypertension, diabetes, and atrial fibrillation); hazard ratio 0.68 (95% CI: 0.64, 0.71). The risk of death did not increase notably until EF fell below 40%. Conclusion Patients with HF-PEF have a lower risk of death than patients with HF-REF, and this difference is seen regardless of age, gender, and aetiology of HF. However, absolute mortality is still high in patients with HF-PEF highlighting the need for a treatment to improve prognosis.
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-6
Journal Detail:
Title:  European heart journal     Volume:  -     ISSN:  1522-9645     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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MeSH Terms
Descriptor/Qualifier:
Investigator
Investigator/Affiliation:
C Berry / ; R N Doughty / ; C Granger / ; L Køber / ; B Massie / ; F McAlister / ; J McMurray / ; S Pocock / ; K Poppe / ; K Swedberg / ; J Somaratne / ; G A Whalley / ; A Ahmed / ; B Andersson / ; A Bayes-Genis / ; C Berry / ; M Cowie / ; R Cubbon / ; R N Doughty / ; J Ezekowitz / ; J Gonzalez-Juanatey / ; M Gorini / ; I Gotsman / ; L Grigorian-Shamagian / ; M Guazzi / ; M Kearney / ; L Køber / ; M Komajda / ; A di Lenarda / ; M Lenzen / ; D Lucci / ; S Macín / ; B Madsen / ; A Maggioni / ; M Martínez-Sellés / ; F McAlister / ; F Oliva / ; K Poppe / ; M Rich / ; M Richards / ; M Senni / ; I Squire / ; G Taffet / ; L Tarantini / ; C Tribouilloy / ; R Troughton / ; H Tsutsui / ; G A Whalley / ; R N Doughty / ; N Earle / ; K Perera / ; K Poppe / ; G A Whalley / ; J Dobson / ; S Pocock / ; K Poppe / ; R N Doughty / ; G Whalley / ; B Andersson / ; C Hall / ; A M Richards / ; R Troughton / ; J Lainchbury / ; C Berry / ; K Hogg / ; J Norrie / ; K Stevenson / ; M Brett / ; J McMurray / ; M A Pfeffer / ; K Swedberg / ; C B Granger / ; P Held / ; J J V McMurray / ; E L Michelson / ; B Olofsson / ; J Ostergren / ; S Yusuf / ; L Køber / ; C Torp-Pedersen / ; Ali Ahmed / ; M J Lenzen / ; W J M Scholte Op Reimer / ; E Boersma / ; P J M J Vantrimpont / ; F Follath / ; K Swedberg / ; J Cleland / ; M Komajda / ; I Gotsman / ; D Zwas / ; D Planer / ; T Azaz-Livshits / ; D Admon / ; C Lotan / ; A Keren / ; L Grigorian-Shamagian / ; A Varela-Roman / ; P Mazón-Ramos / ; P Rigeiro-Veloso / ; M A Bandin-Dieguez / ; J R Gonzalez-Juanatey / ; M Guazzi / ; J Myers / ; R Arena / ; F A McAlister / ; J Ezekowitz / ; P W Armstrong / ; Bibiana Cujec / ; Ian Paterson / ; M R Cowie / ; D A Wood / ; A J S Coats / ; S G Thompson / ; V Suresh / ; P A Poole-Wilson / ; G C Sutton / ; M Martínez-Sellés / ; J A G Robles / ; L Prieto / ; M D Muñoa / ; E Frades / ; O Díaz-Castro / ; J Almendral / ; L Tarantini / ; P Faggiano / ; M Senni / ; D Lucci / ; D Bertoli / ; M Porcu / ; C Opasich / ; L Tavazzi / ; A P Maggioni / ; V Kirk / ; M Bay / ; J Parner / ; K Krogsgaard / ; T M Herzog / ; S Boesgaard / ; C Hassager / ; O W Nielsen / ; J Aldershvile / ; H Nielsen / ; L Kober / ; S M Macín / ; E R Perna / ; J P Cimbaro Canella / ; P Alvarenga / ; R Pantich / ; N Ríos / ; E F Farias / ; J R Badaracco / ; B K Madsen / ; J F Hansen / ; K H Stokholm / ; J Brons / ; D Husum / ; L S Mortensen / ; A Bayes-Genis / ; R Vazquez / ; T Puig / ; C Fernandez-Palomeque / ; A Bardají / ; D Pascual-Figal / ; J Ordoñez-Llanos / ; M Valdes / ; A Gabarrus / ; R Pavon / ; L Pastor / ; J R Gonzalez-Juanatey / ; J Almendral / ; M Fiol / ; V Nieto / ; C Macaya / ; J Cinca / ; A Bayes de Luna / ; J D Newton / ; H M Blackledge / ; I B Squire / ; S P Wright / ; G A Whalley / ; R N Doughty / ; R Kerzner / ; B F Gage / ; K E Freedland / ; M W Rich / ; B C Huynh / ; A Rovner / ; K E Freedland / ; R M Carney / ; M W Rich / ; G E Taffet / ; T A Teasdale / ; A J Bleyer / ; N J Kutka / ; R J Luchic Tribouilloy / ; D Rusinaru / ; H Mahjoub / ; V Soulière / ; F Lévy / ; M Peltier / ; H Tsutsui / ; M Tsuchihashi / ; A Takeshita / ; P A Maccarthy / ; M T Kearney / ; R Cubbon / ; J Nolan / ; A J Lee / ; R J Prescott / ; A M Shah / ; W P Brooksby / ; K A A Fox / ; A Varela-Roman / ; J R Gonzalez-Juanatey / ; P Basante / ; R Trillo / ; J Garcia-Seara / ; J L Martinez-Sande / ; F Gude /

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