| A survey of radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy in Japan. | |
| | |
MedLine Citation:
|
PMID: 18060702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: We observed a rare and unique occurrence of radiation-induced pulmonary injury outside the tangential field for early breast cancer treatment. The findings appeared to be idiopathic and were called radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome. We surveyed major hospitals in Japan to review their findings of radiation-induced BOOP, in particular the clinical and pictorial characteristics of the entity. METHODS AND MATERIALS: We reviewed surveys completed and returned by 20 institutions. The survey responses were based on a total of 37 cases of BOOP syndrome. We also reviewed X-ray and computed tomography scans provided by these institutions. We discussed the information derived from the questionnaire and analyzed patients' characteristics, methods used in the treatment of BOOP syndrome, and prognosis. RESULTS: The incidence of the radiation-induced BOOP syndrome was about 1.8% (37 of 2,056). We did not find a relationship between the characteristics of patients and the occurrence of radiation-induced BOOP syndrome. The pulmonary findings were classified into four patterns on chest computed tomography scans. Progression of the pulmonary lesions observed on chest X-ray was classified into three patterns. Pneumonitis appeared within 6 months after radiotherapy was completed and disappeared within 6-12 months after its onset. At 5-year follow-up, 2 patients had died, 1 of breast cancer and the other of interstitial pneumonitis, which seemed to be idiopathic and unrelated to the radiation-induced BOOP syndrome. CONCLUSIONS: Although the incidence of BOOP syndrome and its associated prognosis are not significant, the patients' clinical condition must be carefully followed. |
| | |
Authors:
|
Etsuyo Ogo; Ritsuko Komaki; Kiminori Fujimoto; Masafumi Uchida; Toshi Abe; Katsumasa Nakamura; Michihide Mitsumori; Kenji Sekiguchi; Yuko Kaneyasu; Naofumi Hayabuchi |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-12-03 |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: 71 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-04-14 Completed Date: 2008-06-09 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
|
Languages: eng Pagination: 123-31 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Kurume University School of Medicine, Kurume, Japan. etsuogo@med.kurume-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Breast Neoplasms / radiotherapy* Cryptogenic Organizing Pneumonia / epidemiology, etiology*, radiography Female Health Care Surveys Humans Incidence Japan / epidemiology Lung / radiation effects, radiography Middle Aged Prognosis Radiation Injuries / complications*, radiography Radiation Pneumonitis / etiology*, radiography Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Warsaw adolescent alcohol use in a period of social change in Poland: cluster analyses of five conse...
Next Document: Late gastrointestinal morbidity after three-dimensional conformal radiation therapy for prostate can...