Document Detail

A survey of diagnostic amniocenteses in Oxford from 1974-1981.
MedLine Citation:
PMID:  2418435     Owner:  NLM     Status:  MEDLINE    
A survey was conducted of the results of mid-trimester diagnostic amniocenteses in the Oxford Region from 1974 to 1981. The survey used data relating to all 4357 singleton pregnancies in which an amniocentesis was performed during this period. Follow-up information on outcome was obtained in respect of 4284 (98 per cent) pregnancies. A cell culture to determine karyotype and an alpha-fetoprotein determination was carried out in all cases. From 1974 to 1981 amniocenteses became increasingly common, rising from 2 to 32 per 1000 births. The most common indication for amniocentesis was a high risk of a chromosome abnormality--56 per cent of all amniocenteses. Within this group advanced maternal age was responsible for 89 per cent of the cases. The next most common indication was a high risk of a neural tube defect (37 per cent of all amniocenteses) --in 1974 a raised maternal serum alpha-fetoprotein level accounted for only 4 per cent of these; by 1981 this had risen to 67 per cent. There were seven false-positive and 132 true-positive diagnoses of neural tube defect; since 1981, with the introduction of amniotic fluid acetylocholinesterase determination as a secondary diagnostic test for neural tube defects, there have been no further false-positive diagnoses. In 1981 76 per cent of women aged 35 years or more did not have an amniocentesis. It is not known to what extent this was due to not offering women in this age group amniocentesis or to women not accepting such an offer.
E Terzian; J Boreham; H S Cuckle; N J Wald; M Bobrow; R Lindenbaum; A C Turnbull
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  5     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:    1985 Nov-Dec
Date Detail:
Created Date:  1986-03-06     Completed Date:  1986-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  401-14     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / etiology
Abortion, Therapeutic
Chromosome Aberrations / diagnosis
Chromosome Disorders
Down Syndrome / diagnosis
Fetal Death / etiology
Maternal Age
Neural Tube Defects / diagnosis
Pregnancy, High-Risk
alpha-Fetoproteins / metabolism
Reg. No./Substance:

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