| A survey of chronic hepatitis B patient management practices in the European Union. | |
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MedLine Citation:
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PMID: 20487257 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The current study sought to evaluate the characteristics of chronic hepatitis B virus (HBV) infection and current management practices in the European Union by surveying physician and patient records. A detailed survey of physician practices and management of patients with CHB was conducted between July and October 2006 in France, Germany, Italy and Spain. A total of 200 physicians participated in the survey, and data were collected from 2023 patients with chronic HBV infection. Most patients were men (69%), who had hepatitis B e antigen (HBeAg)-negative disease (64%), and demonstrated evidence of significant disease [53%; moderate fibrosis (35%), compensated cirrhosis (14%), or decompensated cirrhosis (4%)]. Among the 1665 HBV-monoinfected patients surveyed, 1184 (71%) were currently receiving treatment for chronic HBV infection. At treatment initiation, 70% of HBeAg-positive patients had both pretreatment serum HBV DNA levels <or=9 log(10) copies/mL and alanine aminotransferase (ALT) levels >or=2 x the upper limit of normal (ULN), and 81% of HBeAg-negative patients had HBV DNA levels of <or=7 log(10) copies/mL. Among untreated patients, HBV DNA levels <or=5 log(10,) ALT levels <2 x ULN, and mild or no liver fibrosis were present in 48% and 84% of HBeAg-positive and HBeAg-negative patients, respectively. In conclusion, the majority of European patients with CHB surveyed were HBeAg negative, Caucasian, men, and presented with significant histologic liver disease. At treatment initiation, most HBeAg-positive patients had pretreatment serum HBV DNA levels <or=9 log(10) copies/mL and ALT levels >or=2 x ULN, while the HBeAg-negative patients had HBV DNA levels <or=7 log(10) copies/mL. |
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Authors:
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T Berg; Y Benhamou; J L Calleja; M Levrero; W Johnson; N Ellis |
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Publication Detail:
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Type: Journal Article Date: 2010-05-04 |
Journal Detail:
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Title: Journal of viral hepatitis Volume: 17 ISSN: 1365-2893 ISO Abbreviation: J. Viral Hepat. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435672 Medline TA: J Viral Hepat Country: England |
Other Details:
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Languages: eng Pagination: 624-30 Citation Subset: IM |
Affiliation:
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Sektion Hepatologie, Klinik für Gastroenterologie und Rheumatologie, Universitätsklinikum Leipzig, Leipzig, Germany. thomas.berg@medizin.uni-leipzig.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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