Document Detail

A survey of adult awareness and use of medicine containing acetaminophen.
MedLine Citation:
PMID:  22890688     Owner:  NLM     Status:  Publisher    
PURPOSE: To compare awareness, use of acetaminophen, and preferences for receiving information aimed at reducing acetaminophen overdose. METHODS: A survey of health plan enrollees identified from automated pharmacy data who were long-term and acute users of opioids with acetaminophen (n = 720 each cohort), and a general population cohort (n = 360) during the 2010-2011 cold/flu season. A 74% response rate was achieved. Differences were tested across the three cohorts, and by level of education, using age-adjusted regression models. RESULTS: Use of over-the-counter or prescription medicine containing acetaminophen in the prior 2 weeks was reported by 84% in the long-term opioid cohort, 76% in the acute opioid cohort, and 36% in the general population, but use of over-the-counter medicine with acetaminophen did not differ across the cohorts (30-34%). All three cohorts were unlikely to correctly identify drugs containing acetaminophen, but the opioid cohorts performed slightly better than the general population. Those with higher education performed slightly better when asked to identify acetaminophen products than those with no college education. The average usual daily acetaminophen dose (mg/day) reported was highest in the long-term opioid cohort (1185), followed by the acute opioid cohort (1010), and the general population (891)-p < 0.001. Estimated supratherapeutic exposure (>4000 mg/day) was rare but three to five times more common in the opioid cohorts than in the general population. CONCLUSIONS: Acetaminophen use is common, and supratherapeutic exposure may be of concern in users of opioids. Knowledge of which drugs contain acetaminophen appears inadequate; better labeling and proactive education from professionals may be impactful. Copyright © 2012 John Wiley & Sons, Ltd.
Denise M Boudreau; Heidi Wirtz; Michael Von Korff; Sheryl L Catz; Jackie St John; Paul E Stang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  Pharmacoepidemiology and drug safety     Volume:  -     ISSN:  1099-1557     ISO Abbreviation:  Pharmacoepidemiol Drug Saf     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208369     Medline TA:  Pharmacoepidemiol Drug Saf     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Group Health Research Institute, Seattle, WA, USA; University of Washington, Department of Pharmacy, Seattle, WA, USA.
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