Document Detail

The surprising kidney-fluid mechanism for pressure control--its infinite gain!
MedLine Citation:
PMID:  2246039     Owner:  NLM     Status:  MEDLINE    
In this short paper, I have tried to explain the elation that we felt when we first realized that the kidney-fluid mechanism for controlling the arterial pressure has an infinite feedback gain property. Because of this, all the other pressure control mechanisms, none of which has ever been shown to have a similar infinite gain property, must themselves alter the kidney-fluid mechanism if they are to succeed in causing long-term changes in the arterial pressure. We have not been able to refute this principle despite many experiments over the last 2 decades. For this reason, our first understanding of the infinite gain property of the kidney-fluid mechanism was like a light at the end of the tunnel. I hope that I can explain to the reader the excitement of those few seconds when we first recognized the principle in 1966.
A C Guyton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  16     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-08     Completed Date:  1991-01-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  725-30     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216.
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MeSH Terms
Blood Circulation / physiology
Blood Pressure / physiology*
Body Fluids / physiology*
Hypertension / physiopathology
Kidney / physiology*
Models, Biological
Renin-Angiotensin System / physiology
Vascular Resistance
Grant Support

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