Document Detail

The surprising kidney-fluid mechanism for pressure control--its infinite gain!
MedLine Citation:
PMID:  2246039     Owner:  NLM     Status:  MEDLINE    
In this short paper, I have tried to explain the elation that we felt when we first realized that the kidney-fluid mechanism for controlling the arterial pressure has an infinite feedback gain property. Because of this, all the other pressure control mechanisms, none of which has ever been shown to have a similar infinite gain property, must themselves alter the kidney-fluid mechanism if they are to succeed in causing long-term changes in the arterial pressure. We have not been able to refute this principle despite many experiments over the last 2 decades. For this reason, our first understanding of the infinite gain property of the kidney-fluid mechanism was like a light at the end of the tunnel. I hope that I can explain to the reader the excitement of those few seconds when we first recognized the principle in 1966.
A C Guyton
Related Documents :
2246039 - The surprising kidney-fluid mechanism for pressure control--its infinite gain!
24025799 - Differential effects of antihypertensive treatments on apoptosis, oxidative stress, and...
23540529 - Successful treatment of post-shunt craniocerebral disproportion by coupling gradual ext...
17053539 - Introversion associated with large differences between screening blood pressure and hom...
24588789 - Statistical analysis plan for the 'efficacy of nitric oxide in stroke' (enos) trial.
2711759 - Worksite-screenings for hypertension with follow-up: experiences from the munich blood ...
19712499 - Mechanical ventilation of the neonate: should we target volume or pressure?
8731329 - Evaluation of two different oxygen inspiratory fractions on the hemodynamic effects of ...
22217879 - Blood pressure stability in hemodialysis patients confers a survival advantage: results...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  16     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-08     Completed Date:  1991-01-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  725-30     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Circulation / physiology
Blood Pressure / physiology*
Body Fluids / physiology*
Hypertension / physiopathology
Kidney / physiology*
Models, Biological
Renin-Angiotensin System / physiology
Vascular Resistance
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biometric genetic analysis of blood pressure in the spontaneously hypertensive rat.
Next Document:  Plasma ferritin in the assessment of iron status of Indian infants.