| A surprise cell of origin for Barrett's esophagus. | |
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MedLine Citation:
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PMID: 22549156 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Barrett's esophagus is a metaplasia of the distal esophagus that is the only recognized precursor of esophageal adenocarcinoma. Despite a characteristic histology, the pathogenesis of Barrett's has remained obscure. A recent paper from the laboratories of Wa Xian and Frank McKeon presents evidence for a novel cell of origin of Barrett's. Their work is based on studies of mice engineered to lack the squamous epithelial stem cell survival factor p63. These mice develop a metaplasia of the proximal stomach and esophagus that harbors substantial histological and molecular features of Barrett's. The metaplasia appears to form from embryonic progenitor cells that normally persists post-natally only at the squamo-columnar junction. Moreover, in their model, the metaplasia is initiated not by mutation but by reduced competition between these cells and squamous epithelial cells. |
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Authors:
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Urs von Holzen; Greg H Enders |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-01 |
Journal Detail:
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Title: Cancer biology & therapy Volume: 13 ISSN: 1555-8576 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137842 Medline TA: Cancer Biol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Surgery; University Hospital Basel; Basel, Switzerland; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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