Document Detail

The surgical treatment of hyperinsulinism in infancy and childhood.
MedLine Citation:
PMID:  6317136     Owner:  NLM     Status:  MEDLINE    
Hyperinsulinaemic hypoglycaemia in infancy may be transient or persistent. Persistent hypoglycaemia is caused by nesidioblastosis of the pancreas, a diffuse pancreatic endocrine abnormality involving all the endocrine tissue, or by an islet cell adenoma. The cause of nesidioblastosis is not known but unless controlled its hypoglycaemic effects lead to convulsions, mental retardation or death. Patients with transient hyperinsulinaemic hypoglycaemia, and some with persistent hypoglycaemia, respond to medical therapy but those with an adenoma and many of those with nesidioblastosis will require partial or total pancreatectomy. The surgical treatment of six infants and a child is discussed. Five infants had nesidioblastosis; one infant and one nine-year-old girl had an islet cell adenoma. It is suggested that in the very young when there is no evidence of an insulinoma, resection at the initial operation should be greater--up to 90 per cent--than the previously recommended 75 per cent.
M H Gough
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  71     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-02-21     Completed Date:  1984-02-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma, Islet Cell / complications,  surgery
Hyperinsulinism / etiology,  surgery*
Infant, Newborn
Pancreatectomy / methods
Pancreatic Diseases / complications,  surgery
Pancreatic Neoplasms / complications,  surgery

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