Document Detail

Is surgical resection justified for stage IV colorectal cancer patients having bilobar hepatic metastases?--an analysis of survival of 77 patients undergoing hepatectomy.
MedLine Citation:
PMID:  20872814     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Surgical indication for stage IV colorectal cancer patients with bilobar hepatic metastases may be controversial.
METHODS: Retrospective cohort analysis was performed using data of 200 patients who underwent surgical resections for synchronous metastases of colorectal cancer between 1990 and 2005. Of these, 80 patients had solitary, 43 had unilobar multiple, and 77 had bilobar metastases. Prognostic factors of the 77 bilobar metastases were evaluated using multivariate analysis. The survival was compared with that of 95 patients undergoing chemotherapy for unresectable bilobar hepatic metastases.
RESULTS: Univariate and multivariate analyses revealed that the number of metastasis (≥6) [relative risk (RR), 2.7; P = 0.002] and depth of invasion (T4) (RR, 2.0; P = 0.04) were predictors of survival of the 77 patients. The survival of 11 T4 cancer patients with six or more metastases was poor, but significantly better than that of 95 patients with unresectable bilobar metastases (P = 0.04).
CONCLUSION: Surgical resection in stage IV colorectal cancer patients having bilobar hepatic metastases was justified in the present setting.
Yoshihiro Sakamoto; Shin Fujita; Takayuki Akasu; Satoshi Nara; Minoru Esaki; Kazuaki Shimada; Seiichiro Yamamoto; Yoshihiro Moriya; Tomoo Kosuge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  102     ISSN:  1096-9098     ISO Abbreviation:  J Surg Oncol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  784-8     Citation Subset:  IM    
Copyright Information:
2010 Wiley-Liss, Inc.
Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Cohort Studies
Colorectal Neoplasms / mortality*,  pathology,  surgery*
Liver Neoplasms / mortality*,  secondary,  surgery*
Lymphatic Metastasis
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Retrospective Studies
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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