Document Detail

Is surgical closure of patent ductus arteriosus a safe procedure in premature infants?
MedLine Citation:
PMID:  10096762     Owner:  NLM     Status:  MEDLINE    
Despite indomethacin therapy, many premature infants require surgical closure of their patent ductus arteriosus (PDA). Between January 1985 and December 1997, 176 premature infants underwent surgical closure of PDA by vascular clip after failure of medical treatment. The median gestational age and birth weight were 26 weeks (range 23-36 weeks) and 847.5 g (range 400-2300 g), respectively. The median age at diagnosis and at surgery was 4 days (range, 1-37) and 21 days (range, 4-60) respectively. The median weight at surgery was 982.5 g (range 475-2740 g). Of these infants, 168 (95%) were intubated prior to surgery and the median time to extubation was 21 days (range 1-273 days). There were no operative deaths but 11 infants (6.4%) died from complications of prematurity (sepsis, bronchopulmonary dysplasia and pulmonary hemorrhage). The frequency of chest tube insertion at surgery decreased from 41.7% to 10% between the 1985-88 and 1996-97 periods (P<0.01). Three infants (1.7%) developed vocal cord paralysis directly related to the position of the vascular clip. Echocardiography confirmed PDA closure in 43 infants (24.4%) while the remaining 133 had no clinical signs of PDA. Surgical closure of PDA by vascular clip carries a very low morbidity in premature infants.
J L Russell; J G Leblanc; J E Potts; S S Sett
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International surgery     Volume:  83     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    1998 Oct-Dec
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  358-60     Citation Subset:  IM    
Division of Cardiovascular and Thoracic Surgery, British Columbia's Children's Hospital, Vancouver, Canada.
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MeSH Terms
Body Weight
Chest Tubes
Ductus Arteriosus, Patent / surgery*
Gestational Age
Infant, Newborn
Infant, Premature, Diseases / surgery*
Postoperative Complications

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