Document Detail

The suppression of sucrose intake by cholecystokinin is scaled according to the magnitude of the orosensory control over feeding.
MedLine Citation:
PMID:  6281827     Owner:  NLM     Status:  MEDLINE    
The intestinal hormone cholecystokinin (CCK) has been shown to play a role in the termination of food intake, however its behavioral mechanism of action remains to be determined. Recent work from this laboratory suggested that the suppression of intake with CCK is dependent upon the specific orosensory characteristics of the substance being consumed and that the hormone may suppress intake by altering the behavior maintaining characteristics of orosensory stimuli. The present study further investigated this suggestion by determining whether changes in the orosensory characteristics of food after the magnitude of the suppressive effect of CCK. Specifically, the magnitude of the CCK effect on the intake of sucrose solutions of various concentrations was determined on non-deprived rats. The results of this work indicate that the suppressive effect of synthetic CCK (CCK-8) cannot be overridden by increases in sucrose concentration. In contrast, it was found that over a range of sucrose concentrations, the magnitude of the CCK effect increased with solution concentration. Because sucrose concentration predicts both caloric density and the magnitude of orosensory control (as measured by grams consumed), it appears that CCK may act on this control to regulate meal size in proportion to the caloric density of the food.
R J Waldbillig; T J Bartness
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  28     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  591-5     Citation Subset:  IM    
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MeSH Terms
Cholecystokinin / pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects*
Energy Intake / drug effects
Peptide Fragments / pharmacology*
Satiation / drug effects*
Sucrose / administration & dosage
Taste / drug effects*
Taste Threshold / drug effects
Reg. No./Substance:
0/Peptide Fragments; 25126-32-3/Sincalide; 57-50-1/Sucrose; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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