Document Detail

The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking.
MedLine Citation:
PMID:  1353628     Owner:  NLM     Status:  MEDLINE    
The effects of antidepressants [(+)-oxaprotiline, (-)-oxaprotiline, imipramine, maprotiline, and trazodone] and antihistamines (mepyramine, dimethindene, ketotifen, methapyrilene, and antazoline) on muricidal behaviour in olfactory bulbectomized rats were investigated. All drugs except for dimethindene, which only minimally passes across the blood-brain barrier, suppressed muricide. The drugs which have high affinity for histamine H1 receptor showed potent suppressive effect on muricide. It is suggested that the central histaminergic system is involved via H1 receptors in the expression of muricide in olfactory bulbectomized rats.
S Noguchi; T Inukai; T Kuno; C Tanaka
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  51     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-28     Completed Date:  1992-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1123-7     Citation Subset:  IM    
Biological Research Laboratories, Pharmaceutical Division, Ciba-Geigy (Japan) Limited, Takarazuka.
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MeSH Terms
Aggression / drug effects*
Antidepressive Agents / pharmacology*
Binding, Competitive / drug effects
Dose-Response Relationship, Drug
Histamine H1 Antagonists / pharmacology*
Maprotiline / analogs & derivatives,  pharmacology
Olfactory Bulb / physiology*
Radioligand Assay
Rats, Inbred Strains
Receptors, Histamine H1 / drug effects,  metabolism
Reg. No./Substance:
0/Antidepressive Agents; 0/Histamine H1 Antagonists; 0/Receptors, Histamine H1; 10262-69-8/Maprotiline; 56433-44-4/hydroxymaprotilin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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