Document Detail

The suppression of appetite and food consumption by methylphenidate: the moderating effects of gender and weight status in healthy adults.
MedLine Citation:
PMID:  21733284     Owner:  NLM     Status:  Publisher    
Females typically show greater behavioural responses to stimulant drugs than males, including loss of appetite; as seen, for example, in those who use methylphenidate (MP) therapeutically for treatment of attention deficit hyperactivity disorder (ADHD). This is a relevant issue because of the strong link between ADHD and obesity. In a sample (n=132) of normal-weight (BMI <25) and obese (BMI >30) men and women we assessed appetite, cravings, and snack-food intake in response to MP (0.5 mg/kg) and placebo. Results indicated a significant three-way interaction for the three dependent variables - food-related responding diminishing in all groups from placebo to MP, except in obese males who showed no decreases to the MP challenge. These data show for the first time the existence of gender differences in the appetite response to MP, and are relevant for finding a dopamine pathway to new weight-loss medications, which would be utilized differently in males than in females.
Caroline Davis; Liana Fattore; Allan S Kaplan; Jacqueline C Carter; Robert D Levitan; James L Kennedy
Related Documents :
2658804 - Microcolony epifluorescence microscopy for selective enumeration of injured bacteria in...
19712654 - Assessment of hand washing facilities, personal hygiene and the bacteriological quality...
1457034 - Faecal micro-organisms on the hands of carriers: escherichia coli as model for salmonella.
18767974 - Influence of selective media on successful detection of shiga toxin-producing escherich...
16001154 - Alterations of metabolic enzymes in australian bass, macquaria novemaculeata, after exp...
2279524 - Stud male protection of implantation in food-deprived mice: evaluation of the involveme...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-7
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  -     ISSN:  1469-5111     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-7     Citation Subset:  -    
Faculty of Health, York University, Toronto, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  D-serine adjuvant treatment alleviates behavioural and motor symptoms in Parkinson's disease.
Next Document:  Importance of inter-hemispheric prefrontal connection in the effects of non-competitive NMDA recepto...