Document Detail

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.
MedLine Citation:
PMID:  23321668     Owner:  NLM     Status:  MEDLINE    
HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.
Nichole R Klatt; Lauren A Canary; Xiaoyong Sun; Carol L Vinton; Nicholas T Funderburg; David R Morcock; Mariam Quiñones; Clayton B Deming; Molly Perkins; Daria J Hazuda; Michael D Miller; Michael M Lederman; Julie A Segre; Jeffrey D Lifson; Elias K Haddad; Jacob D Estes; Jason M Brenchley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2013-01-16
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-04-19     Completed Date:  2013-05-13     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  903-7     Citation Subset:  AIM; IM    
National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
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MeSH Terms
Adjuvants, Immunologic / administration & dosage
Anti-Retroviral Agents / administration & dosage*
CD4-Positive T-Lymphocytes / immunology
Combined Modality Therapy
Dietary Supplements
Disease Models, Animal
Gastrointestinal Tract / immunology*
HIV Infections / immunology,  therapy
Macaca nemestrina
Probiotics / administration & dosage*
Simian Acquired Immunodeficiency Syndrome / genetics,  immunology*,  therapy*
Grant Support
261200800001E//PHS HHS
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Anti-Retroviral Agents; 0/Prebiotics
Comment In:
J Clin Invest. 2013 Feb 1;123(2):544-5   [PMID:  23321673 ]

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