| Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. | |
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MedLine Citation:
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PMID: 23321668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis. |
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Authors:
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Nichole R Klatt; Lauren A Canary; Xiaoyong Sun; Carol L Vinton; Nicholas T Funderburg; David R Morcock; Mariam Quiñones; Clayton B Deming; Molly Perkins; Daria J Hazuda; Michael D Miller; Michael M Lederman; Julie A Segre; Jeffrey D Lifson; Elias K Haddad; Jacob D Estes; Jason M Brenchley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2013-01-16 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 123 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-04-19 Completed Date: 2013-05-13 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 903-7 Citation Subset: AIM; IM |
Affiliation:
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National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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administration & dosage Animals Anti-Retroviral Agents / administration & dosage* CD4-Positive T-Lymphocytes / immunology Combined Modality Therapy Dietary Supplements Disease Models, Animal Gastrointestinal Tract / immunology* HIV Infections / immunology, therapy Humans Macaca nemestrina Prebiotics* Probiotics / administration & dosage* Simian Acquired Immunodeficiency Syndrome / genetics, immunology*, therapy* Transcriptome |
| Grant Support | |
ID/Acronym/Agency:
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261200800001E//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Anti-Retroviral Agents; 0/Prebiotics |
| Comments/Corrections | |
Comment In:
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J Clin Invest. 2013 Feb 1;123(2):544-5
[PMID:
23321673
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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