Document Detail


Cu/Zn-superoxide dismutase, paraoxonase and arylesterase activities and malondialdehyde levels in patients with familial mediterranean fever.
MedLine Citation:
PMID:  22979914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: In this study, alterations in antioxidant enzyme activities and malondialdehyde (MDA) levels in the serum samples of patients with familial Mediterranean fever (FMF), an autosomal recessive disease characterized by recurrent episodes of peritonitis, pleuritis, arthritis and fever, were investigated and compared with those of age- and sex-matched healthy controls.
METHODS: Twenty-five patients with FMF undergoing colchicine therapy at doses of 1-1.5 mg and 25 age- and sex-matched healthy controls were included in the study. In the patients with FMF and control subjects, the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level were measured. Cu/Zn-superoxide dismutase (Cu/Zn-SOD), paraoxonase-1 (PON-1) and arylesterase (ARE) enzyme activities and MDA levels as a production of lipid peroxidation were evaluated using the appropriate methods.
RESULTS: No statistically significant differences in the serum levels of ESR, CRP, Cu/Zn-SOD, MDA and PON-1 between the groups were observed (p>0.05). Serum ARE activity was significantly decreased in the patients with FMF compared with the control subjects (p<0.01).
CONCLUSION: In conclusion, some abnormalities in the antioxidant defense system and lipid peroxidation may be observed in FMF patients during attack-free periods. However, further long-term studies on the subject are needed to explore altered lipid peroxidation and antioxidant defense mechanisms in patients with FMF (Tab. 1, Fig. 1, Ref. 35).
Authors:
K Yildirim; H Uzkeser; M Keles; S Yildirim; S Karatay; A Kiziltunc; M Ugur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  113     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-17     Completed Date:  2012-12-05     Revised Date:  2014-01-15    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  561-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aryldialkylphosphatase / blood*
Carboxylic Ester Hydrolases / blood*
Familial Mediterranean Fever / blood*
Female
Humans
Male
Malondialdehyde / blood*
Middle Aged
Superoxide Dismutase / blood*
Young Adult
Chemical
Reg. No./Substance:
4Y8F71G49Q/Malondialdehyde; EC 1.15.1.1/Superoxide Dismutase; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.2/arylesterase; EC 3.1.8.1/Aryldialkylphosphatase
Comments/Corrections
Comment In:
Bratisl Lek Listy. 2013;114(11):668   [PMID:  24236439 ]

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