Document Detail


The superiority of pinacidil over adenosine cardioplegia in blood-perfused isolated hearts.
MedLine Citation:
PMID:  9800829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Our laboratory has shown that the potassium-channel opener pinacidil is an effective cardioplegic agent. A theoretical benefit of cardioplegia with potassium-channel openers is that it arrests the heart at hyperpolarized membrane potentials, a state of minimal metabolic requirement. This study was designed to examine another nondepolarizing agent, adenosine, and to test the hypothesis that it could provide comparable cardioprotection or augment potassium-channel opener cardioplegia. METHODS: Using the blood-perfused Langendorff technique, isolated rabbit hearts were arrested for 30 minutes of global normothermic ischemia. Cardioplegia consisted of either Krebs-Henseleit solution alone (control) or with pinacidil (50 micromol/L), adenosine (200 micromol/L to 1 mmol/ L), or pinacidil + adenosine (200 micromol/L). Recovery of developed pressure and coronary flow were recorded. RESULTS: Postischemic functional recovery for control, pinacidil, adenosine, and adenosine + pinacidil groups was 44.1%+/-3.4%, 59.5%+/-5.2% (p < 0.05 versus control), 37.0%+/-4.5%, and 56.0%+/-2.9%, respectively. CONCLUSIONS: Adenosine, alone or as adjunct to pinacidil cardioplegia, was not an effective cardioplegic agent, despite shorter times to electromechanical arrest than control. The ineffectiveness of adenosine suggests that the cardioprotective properties of potassium-channel openers involve mechanisms other than the avoidance of membrane depolarization.
Authors:
A M Jayawant; R J Damiano
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  66     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-02     Completed Date:  1998-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1329-35; discussion 1335-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Medical College of Virginia, Richmond, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology*
Animals
Blood
Cardioplegic Solutions / chemistry,  pharmacology*
Female
Glucose / chemistry,  pharmacology
Heart / drug effects*
Male
Membrane Potentials / drug effects
Myocardial Reperfusion Injury / prevention & control
Perfusion
Pinacidil / pharmacology*
Potassium Channels / drug effects
Rabbits
Tromethamine / chemistry,  pharmacology
Vasodilator Agents / pharmacology*
Grant Support
ID/Acronym/Agency:
HL-09310/HL/NHLBI NIH HHS; HL-51032/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cardioplegic Solutions; 0/Krebs-Henseleit solution; 0/Potassium Channels; 0/Vasodilator Agents; 50-99-7/Glucose; 58-61-7/Adenosine; 77-86-1/Tromethamine; 85371-64-8/Pinacidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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