Document Detail


A superior semicircular canal dehiscence-induced air-bone gap in chinchilla.
MedLine Citation:
PMID:  20638462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An SCD is a pathologic hole (or dehiscence) in the bone separating the superior semicircular canal from the cranial cavity that has been associated with a conductive hearing loss in patients with SCD syndrome. The conductive loss is defined by an audiometrically determined air-bone gap that results from the combination of a decrease in sensitivity to air-conducted sound and an increase in sensitivity to bone-conducted sound. Our goal is to demonstrate, through physiological measurements in an animal model, that mechanically altering the superior semicircular canal (SC) by introducing a hole (dehiscence) is sufficient to cause such an air-bone gap. We surgically introduced holes into the SC of chinchilla ears and evaluated auditory sensitivity (cochlear potential) in response to both air- and bone-conducted stimuli. The introduction of the SC hole led to a low-frequency (<2000 Hz) decrease in sensitivity to air-conducted stimuli and a low-frequency (<1000 Hz) increase in sensitivity to bone-conducted stimuli resulting in an air-bone gap. This result was consistent and reversible. The air-bone gaps in the animal results are qualitatively consistent with findings in patients with SCD syndrome.
Authors:
Jocelyn E Songer; John J Rosowski
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-07-16
Journal Detail:
Title:  Hearing research     Volume:  269     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-12-28     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  70-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Basilar Membrane / physiopathology
Bone Conduction / physiology*
Chinchilla / physiology*
Cochlea / physiopathology
Hearing Loss, Conductive / physiopathology*
Models, Animal
Semicircular Canals / pathology*,  physiopathology*,  surgery
Vestibule, Labyrinth / physiopathology
Grant Support
ID/Acronym/Agency:
R01 DC000194/DC/NIDCD NIH HHS; R01-DC000194/DC/NIDCD NIH HHS; T32-DC00038/DC/NIDCD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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