| The sunscreening effect of urocanic acid. | |
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MedLine Citation:
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PMID: 8956357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urocanic acid (UCA), present in the stratum corneum, is a major absorber of ultraviolet (UV) radiation and, on UV exposure, is induced to isomerize from the naturally occurring trans-isomer to the cis-isomer. Cis-UCA has been shown to have immunosuppressive properties, while trans-UCA may act as a natural sunscreen due to its UV-absorbing properties. The photoprotective capacity of UCA was investigated in this study. Minimal erythema dose (MED) was determined on normal buttock skin in 36 healthy subjects and the concentration of UCA isomers was measured on the skin adjacent to the test site. On the contralateral buttock. MED was determined 20 min after application of trans-UCA 5% in a cream base. The UCA cream gave a sun protection factor of 1.58. The amount of UCA applied was, however, 20-200 times higher than the amount of UCA found in normal skin, making a sunscreening effect of naturally occurring UCA very low. This was further supported, by a lack of correlation between naturally occurring UCA and the UV sensitivity of each subject determined by the MED. |
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Authors:
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F de fine Olivarius; H C Wulf; J Crosby; M Norval |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Photodermatology, photoimmunology & photomedicine Volume: 12 ISSN: 0905-4383 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1997-03-03 Completed Date: 1997-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: DENMARK |
Other Details:
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Languages: eng Pagination: 95-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Rigshospitalet, University Hospital, Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Humans Isomerism Male Middle Aged Skin / chemistry, pathology, radiation effects* Sunburn / prevention & control Sunlight / adverse effects* Sunscreening Agents* Urocanic Acid* / analysis, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Sunscreening Agents; 104-98-3/Urocanic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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