Document Detail

The sulfinic acid switch in proteins.
MedLine Citation:
PMID:  15254616     Owner:  NLM     Status:  MEDLINE    
Recent studies on the redox behaviour of cysteine residues in peptides and proteins have dramatically changed our perspective of the amino acid's role in biocatalysis, intracellular redox sensing and cell signalling. Cysteine sulfinic acid formation in proteins, for example, has long been viewed as an irreversible 'overoxidation' process that might lead to loss of activity, especially under conditions of oxidative stress. Within the last year, several research groups have independently shown that sulfinic acids can be reduced to thiols in vivo. An enzyme with sulfinic acid reductase activity, called sulfiredoxin, has been isolated from yeast and a gene encoding a human analogue has been identified in the human genome. Reversibility of sulfinic acid formation opens the door to a range of yet unexplored redox cycles, cell signalling processes and reduction mechanisms. These cysteine-based redox processes will be of enormous interest to chemists, biochemists, biologists and the medical community alike.
Claus Jacob; Andrea L Holme; Fiona H Fry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2004-06-29
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  2     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-15     Completed Date:  2004-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1953-6     Citation Subset:  IM    
School of Biological and Chemical Sciences, University of Exeter, Stocker Road, Exeter, United KingdomEX4 4QD.
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MeSH Terms
Cysteine / analogs & derivatives*,  chemistry,  metabolism
Neurotransmitter Agents
Oxidative Stress / physiology
Oxidoreductases / chemistry,  genetics,  metabolism*
Oxidoreductases Acting on Sulfur Group Donors
Proteins / metabolism*
Saccharomyces cerevisiae Proteins
Signal Transduction / physiology
Sulfinic Acids / chemistry*,  metabolism*
Reg. No./Substance:
0/Neurotransmitter Agents; 0/Proteins; 0/Saccharomyces cerevisiae Proteins; 0/Sulfinic Acids; 2381-08-0/cysteine sulfinic acid; 52-90-4/Cysteine; EC 1.-/Oxidoreductases; EC 1.8.-/Oxidoreductases Acting on Sulfur Group Donors; EC 1.8.-/SRX1 protein, S cerevisiae

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