| A sudden awakening from a near coma after combined intake of gamma-hydroxybutyric acid (GHB) and ethanol. | |
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MedLine Citation:
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PMID: 9365424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A case of a sudden awakening from a near coma after combined intake or gamma-hydroxybutyric acid (GHB) (125 micrograms/mL), ethanol (134 mg/dL), and cannabinoids is described. METHODS: GHB was determined by gas chromatography-mass spectrometry after acetonitrile precipitation and derivation with N-methyl-N-trimethylsilyltrifluoroacetamide, using valproic acid as the internal standard. CONCLUSION: The described case illustrates the consequences of GHB overdose. GHB overdose should be considered in every case of unexplained sudden coma, i.e., without any evidence of head injury, intake of coma-inducing drugs, or increasing intracranial pressure. GHB overdose will be missed by routine toxicological screening. |
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Authors:
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H K Louagie; A G Verstraete; C J De Soete; D G Baetens; P A Calle |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of toxicology. Clinical toxicology Volume: 35 ISSN: 0731-3810 ISO Abbreviation: J. Toxicol. Clin. Toxicol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-12-04 Completed Date: 1997-12-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8213460 Medline TA: J Toxicol Clin Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 591-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Biology, University Hospital, Ghent, Belgium. Henk.Louagie@rug.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Intravenous / blood, poisoning* Cannabinoids / poisoning* Central Nervous System Depressants / poisoning* Coma / chemically induced, physiopathology* Drug Interactions Ethanol / poisoning* Female Humans Sodium Oxybate / blood, poisoning* Wakefulness* / physiology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Cannabinoids; 0/Central Nervous System Depressants; 502-85-2/Sodium Oxybate; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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