Document Detail


A sudden awakening from a near coma after combined intake of gamma-hydroxybutyric acid (GHB) and ethanol.
MedLine Citation:
PMID:  9365424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A case of a sudden awakening from a near coma after combined intake or gamma-hydroxybutyric acid (GHB) (125 micrograms/mL), ethanol (134 mg/dL), and cannabinoids is described. METHODS: GHB was determined by gas chromatography-mass spectrometry after acetonitrile precipitation and derivation with N-methyl-N-trimethylsilyltrifluoroacetamide, using valproic acid as the internal standard. CONCLUSION: The described case illustrates the consequences of GHB overdose. GHB overdose should be considered in every case of unexplained sudden coma, i.e., without any evidence of head injury, intake of coma-inducing drugs, or increasing intracranial pressure. GHB overdose will be missed by routine toxicological screening.
Authors:
H K Louagie; A G Verstraete; C J De Soete; D G Baetens; P A Calle
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  35     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1997  
Date Detail:
Created Date:  1997-12-04     Completed Date:  1997-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  591-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Clinical Biology, University Hospital, Ghent, Belgium. Henk.Louagie@rug.ac.be
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthetics, Intravenous / blood,  poisoning*
Cannabinoids / poisoning*
Central Nervous System Depressants / poisoning*
Coma / chemically induced,  physiopathology*
Drug Interactions
Ethanol / poisoning*
Female
Humans
Sodium Oxybate / blood,  poisoning*
Wakefulness* / physiology
Chemical
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Cannabinoids; 0/Central Nervous System Depressants; 502-85-2/Sodium Oxybate; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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