Document Detail


The successful treatment of recurrent nephrotic syndrome with the MOPP regimen in a patient with a remote history of Hodgkin's disease.
MedLine Citation:
PMID:  8172220     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association of Hodgkin's disease and minimal-change nephrotic syndrome is well established. We describe a gentleman who developed Hodgkin's disease that was treated successfully. Two years later, he developed minimal-change nephrotic syndrome that responded to steroids. Over the next 9 years, the patient experienced two episodes of nephrotic syndrome due to focal segmental glomerulonephritis that were successfully treated with the mustard/vincristine/prednisone/procarbazine (MOPP) regimen. There was no evidence of recurrence of Hodgkin's lymphoma during any episode of nephrotic syndrome.
Authors:
J A Delmez; S H Safdar; J M Kissane
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  23     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-05-27     Completed Date:  1994-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  743-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Washington University School of Medicine, St Louis, MO.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Hodgkin Disease / complications*
Humans
Male
Mechlorethamine / administration & dosage
Middle Aged
Nephrotic Syndrome / drug therapy*,  etiology
Prednisone / administration & dosage
Procarbazine / administration & dosage
Recurrence
Vincristine / administration & dosage
Grant Support
ID/Acronym/Agency:
NIDDK/DK-07126/DK/NIDDK NIH HHS; NIDDK/DK-09976/DK/NIDDK NIH HHS; NIDDK/RR-00036/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/MOPP protocol; 51-75-2/Mechlorethamine; 53-03-2/Prednisone; 57-22-7/Vincristine; 671-16-9/Procarbazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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