Document Detail

The successful treatment of prurigo pigmentosa with macrolide antibiotics.
MedLine Citation:
PMID:  11244235     Owner:  NLM     Status:  MEDLINE    
Recent studies have demonstrated that macrolide antibiotics have anti-inflammatory as well as antibacterial effects. Therefore, macrolide antibiotics have been successfully used to treat patients with various inflammatory diseases. We evaluated the effect of macrolide antibiotics in 4 patients with prurigo pigmentosa who were treated with either 400 mg of clarithromycin or 300 mg of roxythromycin daily. Eruption and pruritus disappeared within a week in all the patients while those symptoms were unresponsive to other drugs. Although the mechanism of this effect remains unclear in patients with prurigo pigmentosa, macrolide antibiotics can be considered as an alternative treatment for prurigo pigmentosa.
N Yazawa; H Ihn; K Yamane; T Etoh; K Tamaki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  202     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-13     Completed Date:  2001-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  67-9     Citation Subset:  IM    
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Clarithromycin / therapeutic use
Middle Aged
Pigmentation Disorders / drug therapy*,  pathology
Prurigo / drug therapy*,  pathology
Roxithromycin / therapeutic use
Skin / drug effects,  pathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 80214-83-1/Roxithromycin; 81103-11-9/Clarithromycin

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