Document Detail


A successful outcome of pregnancy in a patient with congenital antithrombin deficiency.
MedLine Citation:
PMID:  21452673     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Presence of inherited thrombophilia is an additional risk factor for maternal thromboembolism and certain adverse pregnancy outcomes, including recurrent fetal loss, placental abruption, intrauterine growth restriction and early-onset severe preeclampsia. Pregnant women with thrombophilia, especially those with antithrombin (AT) deficiency, are at high risk of both kinds of complications.
CASE REPORT: We presented a pregnant women with congenital antithrombin deficiency in the first pregnancy, whose mother had had four times pregnancy-related deep vein thrombosis, and antithrombin deficiency. With the regular laboratory monitoring of hemostatic parameters and gynaecology surveillance including the follow-up of placental vascular flow, the whole pregnancy proceeded without complications. The prophylactic therapy with low molecular weight heparin was introduced from the 20th week of gestation and one dose of substitution therapy with antithrombin concentrate was administrated before delivery. Pregnancy and labour were terminated without complications at the 37th week of gestation, resulting in the delivery of a healthy male newborn of 3.6 kg body weight, 52 cm long, and with the Apgar scores of 9/10.
CONCLUSION: A timely made diagnosis of thrombophilia, accompanied with regular obstetrics check-ups and follow-ups of hemostatic parameters during pregnancy, as well as the use of adequate prophylactic and substitution therapy, are the successful tools for the prevention of possible maternal complications and pregnancy itself in our patient with congenital AT deficiency.
Authors:
Mirjana Kovac; Zeljko Miković; Ljiljana Rakirević; Snezana Srzentić; Vesna Mandić; Valentina Djordjević; Dragica Radojković
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vojnosanitetski pregled. Military-medical and pharmaceutical review     Volume:  68     ISSN:  0042-8450     ISO Abbreviation:  Vojnosanit Pregl     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  21530700R     Medline TA:  Vojnosanit Pregl     Country:  Serbia    
Other Details:
Languages:  eng     Pagination:  175-7     Citation Subset:  IM    
Affiliation:
Blood Transfusion Institute of Serbia, Hemostasis Department, Belgrade, Serbia. mkovac008@gmail.com
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