Document Detail

The subtle facial signs of prenatal exposure to alcohol: an anthropometric approach.
MedLine Citation:
PMID:  11487746     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose was to demonstrate that an objective, multivariate case definition of fetal alcohol syndrome (FAS) and partial fetal alcohol syndrome (PFAS) can be derived by means of craniofacial anthropometry. STUDY DESIGN: Craniofacial measurements (n = 21) were taken of 100 individuals who had been exposed to alcohol before birth (41 FAS, 59 PFAS) and 31 members of a control group. Multivariate discriminant analysis was used to identify craniofacial measurements that best differentiated the 3 groups (FAS, PFAS, and control). RESULTS: Both the FAS and PFAS groups had a unique craniofacial phenotype that could be accurately discriminated from that of the control group. Stepwise discriminant analysis identified 6 craniofacial measurements that could differentiate individuals with and without prenatal alcohol exposure with 96% accuracy, 98% sensitivity, and 90% specificity. CONCLUSIONS: Individuals with FAS and PFAS have a distinctive facial phenotype that can be characterized anthropometrically. The phenotypic case definition could be used as a screening tool to identify individuals prenatally exposed to alcohol who do not exhibit a "classic" FAS phenotype but exhibit a more subtle craniofacial dysmorphia.
E S Moore; R E Ward; P L Jamison; C A Morris; P I Bader; B D Hall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  139     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-06     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  AIM; IM    
St. Vincent Hospitals and Health Services, Indianapolis, IN 46240-0970, USA.
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MeSH Terms
Case-Control Studies
Craniofacial Abnormalities*
Discriminant Analysis
Fetal Alcohol Syndrome / diagnosis*
Prenatal Exposure Delayed Effects
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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